Kratom is one controversial drug when it comes to legality issues and drug testing. As this drug has been used for years be people for relieving pain and for the withdrawal of opium, it has become a necessity of time. Unfortunately the more commonly it is used, the less research has been done on this drug. This brings us to a blind end. Is it safe to consume Kratom? Is it an efficient pain killer? Is it opium? Can it appear on drug tests? Can it cost you, your money, health as well as the job? To have a detailed look at the topic at hand let’s just first review the concept of drug testing, false positives, and false negatives.

What are drug testing, false positives and false negatives?

According to Wikipedia, a drug is a chemical and technical analysis of a biological specimen. These samples include urine, blood, breath, hair, sweat or saliva. It is done to determine the presence of a drug or its metabolites.

It detects drugs that enhance performance in sports (steroids), alcohol, and medications that are prohibited like cannabis, cocaine, and heroin.

Most commonly urine drug test (UDS) is used as it is quick and accurate. It screens for the presence of certain illegal drugs and prescription medications that include alcohol, amphetamines, benzodiazepines, marijuana, opioids, etc.

Sometimes UDS doesn’t pick up on all drugs especially opioids, and thus it gives false positives, A false positive happens when the test results are positive for a drug that you haven’t consumed. In this case, you should request for another test known as Gas chromatography/mass spectrometry (GC/MS).

UDS can also give false negatives, which is when the test result is negative even though there is a usage of that particular drug.

Readers review about drug testing of Kratom

Some users reported that when tested, Kratom doesn’t give positive test results. These users were of the view that since Kratom is not opium it won’t show up on the test and neither are the active metabolites in any way resembling opium, so it’s justified that Kratom can’t be detected.

Drug screening tests are more commonly abused and kratom is not a drug of abuse. Therefore it’s not included in any screening test. Neither is Kratom an illegal drug that needs to be checked. It’s allowed in many parts of the world and in countries like Malaysia and Thailand where Kratom is banned, it’s just because the trade of opium stopped generating revenues when Kratom got introduced. These users claimed that none of the alkaloids present in this drug would show up in most of the standard drug tests.

Some other users claim that Kratom gives false positives on the test result. One user narrated that he went for some drug screening at his office and the test result came false positive for Methadone.

Another reported that his result was false positive for marijuana and thus he was rejected for the job. In such conditions, it is recommended that you go for GC/MS because Kratom or its metabolites won’t appear on this method of screening. Unfortunately, many companies use UDS when appointing newcomers, and if it comes false positive, then you are not given the job.

Another class of users reported that if Kratom is taken with certain other potentiating drugs, then it shows up on the screening test, giving a false positive. They were using DXM, Benadryl, and Prozac to enhance the effects of Kratom. Their test result was either false positive for opiates or benzodiazepines. Therefore they suggested not taking any potentiating drugs with Kratom, in case one is going for a screening test.

Users also claimed that if you take these potentiating medicinal products in a dose greater than recommended dose, only then would it give false positives. Even some over the counter medications give false positives that include using a nose spray and showing a positive result for methadone. Consuming Ibuprofen in high doses and indicating a positive result for Marijuana. This signifies that UDS isn’t effective so go for lab testing because it will give the negative effect for Kratom.

Many users wrote on Reddit that if Kratom is tested within 12 hours of consumption, it won’t show up on the test. It makes us believe that some of the metabolites of Kratom are responsible for generating false positive results.

Is there any drug screening test for Kratom?

Luckily, no! There is no Kratom screening test. The reason being that many people are not aware of the drug and that it is considered a medicinal herbal drug that doesn’t cause profound CNS effects. Moreover, it’s legal. You can use it in many parts of the world without any worry or trouble. So the standard screening tests are not oriented towards the detection of Kratom in the body. However, some companies have designed specific tests for Kratom just because of lack of information and anti-drug hysteria. This has also resulted in legality issues.

Recently the US have decided to ban the drug, causing trouble for all those users who use it to kill chronic pain or to withdraw from opium.

Can I use kratom before a drug test?

It is recommended not to consume any strain of Kratom at least a week preceding to the drug test. Companies don’t hire you if you show up with a false positive on the standard drug test.

They don’t wait for lab tests, so you get fired, or you don’t get hired at all.

Therefore do not take any CNS stimulants or depressants before the drug screening test as it can give you trouble. Though Kratom is not tested generally, yet many users claim that it gives false positives so we will accept what the majority says and suggest you not to use kratom before a test.

The post Does Kratom Show Up on Drug Testing? appeared first on Kratomguides.com.

Kratom and Phenibut combination is something that is trending these days! Do you want to be as calm as cradled child in dreamland slumber? Do you want to be as efficient as possible? Do you want to be euphoric? Do you want to socialize without any worry on mind? Do you want to enjoy every moment of your life? You are at the right avenue because we are going to explain all the beneficial effects of the Kratom and Phenibut mixture! It’s a dream combo.

Phenibut and Kratom combination is what you need today to forget all your worries and work efficiently. But of course, with every good comes something bad. We ask you to be cautious when it comes to regular consumption and amount of drug consumed. Have a look at these wonder drugs!

What is Phenibut?

Phenibut, chemically known as β-Phenyl-γ-aminobutyric acid is a drug that resembles a particular chemical in the human brain which is known as gamma-aminobutyric acid or GABA for short. This medication was first discovered in the Soviet Union during the 1960s.

Phenibut is used for various mental and emotional maladies. Most commonly it used as an anxiolytic drug. It also helps in improving sleep pattern, countering fear and stress. It is also utilized in the treatment regimen of alcoholism, stuttering, asthenia and vestibular disorders. It is more of a nutritional supplement, but it is not approved in the United States. However, in Russia, it is used as a psychotropic.

It is a central nervous system depressant and readily crosses blood-brain barrier due to the phenyl ring present in it. It also acts as an antagonist/blocker at of α2δ subunit-containing voltage-gated calcium channels.

How do Phenibut works?

It is interesting that many users give reviews that Phenibut helped them deal with anxiety and fear issues, but this drug, as Kratom has not been studied in detail. We do not have any academic papers written on this medication, however since it is similar to GABA, it acts on the GABA receptors in the brain. It is an agonist of the GABA receptor, and at higher doses, it also has an affinity for GABAA receptors.

According to Shulgina (1986) and Allikmets and Ryage (1983), Phenibut attaches to GABAA receptors eliciting responses like benzodiazepines and barbiturates. However, Lapin (2001) states otherwise.

It has nootropic effects, eliciting a tranquilizing effect, reduction in fear and anxiety, improvement in sleep pattern and enhancement of effects of narcotics and neuroleptics as well as Kratom. Anecdotal evidence suggests that Phenibut can induce euphoria by increasing the levels of dopamine in the striatum.

Why do people take Phenibut?

At higher does, you will sleep like a baby

According to users, when you take Phenibut at as high doses as 1000-2000 milligrams just an hour before sleeping, you will have a very peaceful sleep. Phenibut reduces the sleep induction time and increases the slow waves sleep period by reducing rapid eye movement sleep period. You will not experience a dream, tossing or turning around. You go into a state of deep sleep where disturbances like phone calls; door bells etc. won’t affect you. When you wake up, you feel rested and refreshed.

You will be more sexually aroused

An unexplained effect many users state they become more sensitized, and they have better orgasms. They are more aware of their body parts and the sense of touch after they take Phenibut. Thus their sexual experiences are more of fun!

It relieves anxiety, post-traumatic stress disorder and alleviates fear and tension

Taking Phenibut will give you a sense of calmness that you have never experienced before. You will feel moderate to a drastic reduction in social or general anxiety disorders. You will prefer socializing and interacting with people. You will observe a sense of confidence while talking to people and doing day to day tasks.

Phenibut enhances the feeling of well-being, and you can even achieve euphoria by consuming a moderate dose of Phenibut. You will also feel an increase in alertness and improvement in cognitive processes. It also helps you retain memory and enhances your motivation.

Kratom and Phenibut combination

Kratom and Phenibut have certain similarities regarding the physical effects the two drugs produce, but the cognitive effects vary from person to person. If you combine Phenibut with Kratom, you will potentiate the effects of Kratom, and thus the effects will last longer. So when you are taking Phenibut and Kratom combination, bear in mind that you will have increased pain threshold, more sedating effects, and no anxiety.

Phenibut’s longevity and Kratom’s euphoria is something that people desire. Phenibut help extends the effects of Kratom. It energizes you when used in combination with Kratom; it makes you feel more active and optimistic.

Effects that you feel after Kratom Consumption

• Euphoria
• Mental stimulation
• Analgesia
• Mood-boost

Effects that you feel after Phenibut Consumption

• Muscle Relaxation
• Strong sense of calmness and well-being
• Sedation

Phenibut and Kratom Effects at Different Doses

At high doses

High doses of Phenibut mean a dose above 2500mg. At this dose, you will experience extreme sedation, and you will go to a coma-like sleep.  Same is the case with Kratom. High doses of Kratom means between the ranges of 4.5-8 grams. If you consume such high doses, you will get sedated, and you might experience nausea and vomiting. It is however recommended to avoid such high doses as it leads to quick tolerance.

At medium doses

For Phenibut medium dose means something between 500mg to 1500mg. At this dose, you will experience the soothing and calming effect. You will forget your worries, and you will feel more enthusiastic and ecstatic. The moderate dose for Kratom is 2-4.5 grams. At moderate doses of kratom, you will experience more efficiency as it has a stimulatory effect.

At low doses

Small doses of Phenibut come in the category of 500mg and below. It is very likely that initially this amount will work for you and you will euphoric, but with more usage, you will find that you don’t experience anything at such small doses. Low dose for Kratom is 1-2grams. It acts as an analgesic at this dose and causes mild euphoria.

Maeng Da Kratom and Phenibut Combination

According to users on different drugs forum and Reddit, combining Maeng Dan ad Phenibut takes you to the next level. The optimal dosage to get the desired effects is somewhere between 1-1.5grams for Phenibut and 5-7.5grams for Maeng Da. Taking the combination on an empty stomach will result in effects within an hour. The results are totally amazing, and it makes you high.

The effects that you are likely to experience due to Maeng Da includes that you will get highly energetic. You will feel a sense of euphoria, and you will be more mentally alert and focused. It boosts mood and causes analgesia. Phenibut will soothe you and calm your agitated nerves. It will cause relaxation of the muscles. It will help you socialize better.

Red Kratom and Phenibut Combo

Red strains of Kratom are supposedly more sedating and relieving pain. Red Kratom and Phenibut combination will result in soothing effects as well as reduction of anxiety and stress.

Red kratom in a dosage of 6-7 grams and Phenibut in a dose of 1gram, will act as anxiolytic and give you a sense of calmness and well-being. Red Kratom tends to potentiate the effects of Phenibut thus combating general anxiety disorders, post-traumatic stress disorders, etc.

Phenibut and Kratom combination side effects

When you are taking Kratom and Phenibut combination, bear in mind you are dealing with two drugs that have consequences leading to dependence and tolerance. So if Phenibut acts by potentiating Kratom, it also elevates the risk of tolerance and dependence on Kratom.

Moreover, Phenibut itself cause dependence and severe withdrawal symptoms. Therefore, it is suggested that when taking the two drugs in combination, do not use Phenibut daily.

Take 2-3 days off in a week or go for cycling which means a period of 2 weeks ON and a period of 2 weeks OFF. The reason tolerance increases because the GABA receptors become desensitized to the effect of the drug or they are down-regulated.

Just like Kratom, with Phenibut you will not experience a hangover. Instead, you will experience the Phenibut ‘afterglow.’

Some users reported that with continuous use of Phenibut they experience slight numbness and limb pain after hours of sleep while others reported a loss of libido and erectile dysfunction.

According to Reddit users, they also felt side effects like grogginess following the continuous use of Phenibut with Kratom. They also complained of constipation, blurred vision with less ability to focus. Users also claimed that they suffered from rebound insomnia or sleep problems after stopping the regular use of this combination.

Some users reported severe side effects like memory retention problems, severe dizziness, nausea and vomiting and development of psychosis and delusional state.

Kratom and Phenibut Precautions

The Kratom and Phenibut combination are potentially addictive, and it is very powerful. It could lead to replacement addiction if you are using this combination for opiate withdrawal. You need to be extra careful with dosing as higher doses can result in unpleasant effects. Use these drugs responsibly and appropriately educate yourself about both drugs before consuming them. Do not overdose yourself and abstain from using Phenibut regularly as you can get addicted to it and it also produce tolerance.

References:

http://www.webmd.com/vitamins-supplements/ingredientmono-1184-phenibut.aspx?activeingredientid=1184&activeingredientname=phenibut

https://liftmode.com/blog/what-is-phenibut/

https://en.wikipedia.org/wiki/Phenibut

https://www.smartdrugsforthought.com/what-is-phenibut/

http://www.raysahelian.com/phenibut.html

http://nootriment.com/phenibut/

http://opiateaddictionsupport.com/phenibut-and-kratom-combination-mixing/

The post Effects of Kratom and Phenibut Combinations appeared first on Kratomguides.com.

People go for Benzodiazepines or SSRI’s to control their anxiety, but recently the combination of Phenibut and Kratom has proved fruitful for the treatment of Anxiety. Phenibut and Kratom combination has helped many anxious patients to continue a healthy life, soothing and calming them, reducing their worries and boosting their moods. This mixture of Kratom and Phenibut has enabled many people to get back to a happy life with fewer problems. To study Kratom and Phenibut combination in greater detail, let’s have a look at this disorder first.

What is anxiety?

Anxiety is a generalized term that is used for some disorders including panic, social anxiety disorder, specific phobias and generalized anxiety disorder. The general symptoms of anxiety include a feeling of panic, fear and uneasiness, impaired sleeping, sweaty and cold hands, hypoventilation, palpitations, dryness of mouth, tense muscles, nausea, paresthesia of extremities, etc. Anxiety stops people from going to places which make them anxious, from taking exams that give them cold hands and taking interviews which make them jittery.

How does Phenibut acts like an ANXIOLYTIC?

Beta-phenyl-gamma-aminobutyric acid or Phenibut is a neuropsychotropic drug that serves as an anxiolytic and as a nootropic, improving cognition. It mimics GABA and acts on GABA (B) receptors primarily and secondarily at GABA (A) receptors. It has dopaminergic activity and serves as an antagonist of beta-phenylethylamine. It is widely used in different parts of the world, especially Russia to cure ailments like tension, anxiety, fear and sleep disorders.

Since it mimics GABA, it acts in the same way benzodiazepines do. It gets attached to GABA receptors and potentiates GABAergic activity. It increases the frequency of GABA-mediated chloride ion channel opening. As a result, it helps in reducing anxiety states.  Phenibut is favored in the treatment of acute anxiety state and for rapid control of stress and it also has remedial actions.

Kratom and Phenibut Combination for Anxiety

Together Kratom and Phenibut give you a sense of well-being, and it soothes your nerves.  Though individually the two drugs are known for sedatives effects but together they have a very marked effect. There is this overwhelming sense of well-being after consumption of the two drugs.  You feel relaxed and calm. You will feel a noticeable reduction in anxiety and nervousness. Kratom has an effect that lasts for a shorter time, but when taken in combination with Phenibut, the effects will last longer. It is crucial that you take the right dose to avoid sleeping in case you have an upcoming interview or an appearance somewhere.

Phenibut and Kratom, The right dose for ANXIETY

Kratom has different strains, and these strains are useful for various ailments. Speaking about Kratom, we should mention that Red Kratom is particularly responsible for producing calming effects and for treating anxiety. So the doses that are going to be mentioned are, particularly for Red Kratom. Although you will get sedating effects with Kratom, users report that at small doses of Kratom one usually experiences mood stimulation and gets the energetic feeling. A little moderate dose of 2-4.5 grams of Red Kratom kills anxiety. Phenibut should always be started at subtle doses. Start with 500milligrams. If you do not feel any effect, then you can maximally increase up to 1500milligrammes. After this dose, it is entirely possible that you will sleep due to too much sedation. Therefore it is suggested that you take these two drugs in very careful doses as to avoid sleeping.

How to take Phenibut and Kratom together?

It is recommended that you take the two drugs on an empty stomach as food delays the absorption of Kratom and Phenibut. Since Kratom has a very disgusting taste, you can take it in the form of a capsule, and you can take Phenibut in a similar way. However, you need to take a stimulant drink after the consumption of Phenibut and Kratom combination. Most users go for coffee while many others go for energy drinks. Wait for an hour to observe noticeable effects.

Take it in the morning or 2-3 hours after your last meal. If you take it on a full stomach, the effects will appear late. The effects last for almost 12-14 hours.

Phenibut and Kratom Precautions

It is important that you don’t take this combination daily as it can lead to tolerance and severe withdrawal symptoms. Moreover, you need to keep the dose in check; otherwise, increased doses can result in severe GIT distress, nausea, and vomiting. According to users, it may even cause stomach ulcers as Phenibut is acidic in nature.

According to users, the combination is very harsh if the doses are increased as Kratom hits the mu receptors and Phenibut hits the GABA receptors. If overdoses, it can lead to severe inhibition and can prove fatal.

Moreover, Phenibut is incredibly addictive, and it causes serious withdrawal symptoms. Phenibut addiction can develop within ten days, and its removal can prove fatal as it causes sleeplessness and rebound anxiety.

Side Effects of Phenibut and Kratom combination

Phenibut and Kratom if taken at higher doses can cause too much sleepiness. It can be avoided by taking stimulants like caffeine. If you take the combination at night before sleeping, make sure you take small doses as it can cause oversleeping. You can quickly build a tolerance to Phenibut. To avoid this issue, it is necessary that you do not take Phenibut more than three times in a week. The less often you use this drug, the more often it works for you. Phenibut and Kratom both have a potential for addiction and dependency, though it is quite small. You can experience a slight headache after taking the combination.

Before consuming the mixture, note that you do not have any other systemic diseases as these two drugs can aggravate certain conditions. Make sure that you are also not taking any prescribed drugs whose action can be counteracted by the combination of Kratom and Phenibut. Always consult your doctor before starting any drug regimen.

References:

http://opiateaddictionsupport.com/phenibut-and-kratom-combination-mixing/

https://drugs-forum.com/forum/showthread.php?t=188030

http://www.personalpowermeditation.com/forum/drugs/anyone-tried-phenibut-and-kratom-before/

http://roosterdating.com/phenibut-guide/

http://www.pillscout.com/supplements/phenibut-social-anti-anxiety-drug/

http://www.entheogen-network.com/forums/viewtopic.php?f=10&t=15054

http://getsmartdrugs.com/phenibut-and-kratom-for-anxiety/

https://erowid.org/experiences/exp.php?ID=95501

https://www.ncbi.nlm.nih.gov/pubmed/11830761

https://www.reddit.com/r/kratom/comments/4oudv7/phenibut_and_kratom_is_a_great_combo/

https://www.reddit.com/r/Drugs/comments/3zigeg/to_the_all_people_who_take_phenibut_recreationally/

https://www.anxietybc.com/sites/default/files/What_is_Anxiety.pdf

http://www.webmd.com/anxiety-panic/guide/mental-health-anxiety-disorders

The post Phenibut and Kratom Combination For Anxiety appeared first on Kratomguides.com.

The Kratom Syndicate (TKS) is an online Kratom retailer that specializes in different strains of Kratom as well as alternatives of Kratom that includes Mitragyna Javanica, Akuamma seeds, Kava, Phenibut, Tianeptine, Sakae Na, etc.  These drugs are commonly used to relieve conditions like anxiety and stress disorders. They also boost mood and enhances mental stimulation. To know more about thekratomsyndicate.com, read the review below.

What is The Kratom Syndicate?

The Kratom Syndicate can be found on their customer friendly website thekratomsyndicate.com. The company claims that it sells the best and highest-quality Kratom strains and different alternatives of Kratom. They have a vast stock of different herbs that can be used to stimulate one mentally and to generate a state of euphoria.

The best part of ‘The Kratom Syndicate’ is that they ship Kratom and its alternatives all over the world, with exception to the countries where Kratom has been explicitly banned. They provide the highest quality Kratom at very reasonable prices and what amazed me was that they have a lot of discounts and coupons for the customers.

So if you are looking for a type of Kratom that is not available from other vendors, and that has the finest quality, you need to check this website thekratomsyndicate.com.

What are the different Products available at The Kratom Syndicate?

At their website thekratomsyndicate.com, the following herbs are available. You need to notice the affordable range of the prices.

• Mixed Vein Maend Da – $9.99
• Red Kapuas- $38
• Green Kapuas- $38
• 50X Kratom Extract- $40.50 instead of $45
• Red bali- $38
• Akuamma Seeds- $16
• Green Maeng Da- $9.99
• Red Maeng Da- $9.99
• Sakae Naa (Combretum Quadrangulare) 10:1 extract -$12
• Incarvillea Sinensis 20:1 Extract- $12
• Kava Extract 30% Kavalactones- $13
• Mitragyna Javanica- $14.99
• Phenibut HCL 99.5+% PURE- $19
• Anjungan Plus+ -$19
• Enhanced Hirsuta-$27
• Tianeptine Sodium- $63

What are the varieties of Kratom available at The Kratom Syndicate?

As the name implies, this site offers a range of Kratom strains. It is clearly noticeable that The Kratom Syndicate has mixed different strains of Kratom to produce a mixture which is more efficient in producing the desired effects. They sell one of the finest Kratom strains available.

I tried the Kratom Syndicate last month, and I realized that the Kratom I have been purchasing from other vendors is not as excellent as the one I bought from here. I felt effects at the smallest dose of 2g, while usually, I do not feel any effects at 5g even. I must say the Kratom sold by ‘The Kratom Syndicate’ is very potent and shows me a large amount of love.

I consistently get 100% organic Kratom with the amazing aroma from ‘The Kratom Syndicate’ with half of the amount of Kratom I would require from other suppliers. They have some real Kratom in stock!

Moreover, I would like to add that the Kratom sold by this vendor is most definitely very fresh. I would like to add an individual review of the strains that I have tried.

50X Kratom Extract

It is one of the best Kratom extracts on the website. It is pure love, very relaxing, enhances mood and potent at a 1-2g dose. It is a powerful extract. Though it seems a little pricey, you can always avail it on discount.

Red Kapuas

Perfect aroma, with excellent packaging, I must say I had one awesome experience! It elevated my mood and helped me with my chronic back pain. This strain makes me visit TKS again and again. I must say it is my happy strain because the euphoria that comes with it is so relieving.

Green Maeng Da

This is a well balanced Kratom strain that kept me active throughout the day and helped me with my chronic pain. I also felt that it relieved my anxiety.

Ultra Enhanced Kratom

It will not disappoint you. An adamant extract-mixed powder, which surprised me! It is great for pain and gave me a feeling of well-being. Its effects lasted for a long duration of time. The price is quite reasonable for an ultra-enhanced Kratom, totally amazed me!

You will be pleased once you visit the website of The Kratom Syndicate. They have all varieties of Kratom ranging from slow to fast Kratom strains. At the time of writing this, there are about 20 options in their inventory. Thus you are guaranteed to find a perfect variety that works for you well!

What are the alternatives of Kratom available?

Though the name of the vendor suggests that it is just selling Kratom, actually there is more to it. The Kratom Syndicate offers the best alternatives of Kratom at very reasonable rates that are totally affordable, so yeah worth trying! I have had ordered Phenibut from TKS. I was astounded at the effects it immediately produced, unlike the Phenibut I get from other vendors. I was wondering the reason behind it, and then I realized that the claim about Phenibut they have on their website i.e. 99.5%+ PURE is right! I did not stop here. I also tried Kava. I must say that is the most energetic Kava tea that I had. The effects lasted longer and gave me a sense of well-being. I usually mix Kava with strains of Kratom to potentiate the effects, but I had never come across a Kava like this, which worked so well even without Kratom.

You can also have a look at the other alternatives that they are selling. I have not come across any other Kratom vendor, which has such a large variety of options to Kratom. They have all their products labeled about the effects which help the customer decide on buying the right stuff.

Why would you particularly love the Packing of Products?

So they ship their products maintaining the integrity of the product. It is properly wrapped and sealed. Inside the wrapping, you will find those cute tins. I totally loved the package when I opened it. So all the products that The Kratom Syndicate ships, are contained within those tiny tins that are also shown on their website. They are not just fancy, but they are air tight, keeping the product safe from oxidation by air.

Do you think ‘The Kratom Syndicate’ is expensive?

I believe it is not at all expensive, considering the quality of the products.  I mean to say if you buy a Red Bali from TKS, the only 1-2g dose will start producing effects, but if you buy the same product from another vendor, the results will not even show up at a high dose like 5-7g. This means that you are paying for something good that will last longer.

It is entirely irrelevant to say that ‘The Kratom Syndicate’ is expensive as some of their products like Ultra Enhanced Kratom are cheaper than that sold by other vendors. Moreover, you have many discounts on products, and you can even get coupons. You can be a part of the contests that they announce on their Facebook and via newsletter to win some pretty incredible strains!

What is the ‘The Kratom Syndicate’ meme contest?

The Kratom Syndicate has a policy of engaging and benefitting customers in all possible ways. They have the regular ‘Meme Contest’ on their Facebook page. In the contest, the users have to make memes related to Kratom. The person who posts the best Kratom meme gets 50 grams of 50x extract that is worth $200! In this way, TKS gifts their customers. No wonder why we all love The Kratom Syndicate.

Is it easy to buy from The Kratom Syndicate?

To judge a vendor, you should also consider the ease of making an order and the overall experience from purchasing on their website to getting the product. You can pay by credit card and they have this new feature of ‘store credit ‘on their website, which can help you share credit with your friends.

They also accept coupon codes. You need to pay a certain amount of shipping costs that you can find in their ‘order and shipping policy’. You need to ensure the legality of the product in your country before making an order. If you get any problem within the first ten days of order confirmation, make sure you contact The Kratom Syndicate.

I think that ‘the Kratom Syndicate’ makes it very easy for us to navigate on their site for different products and see their prices. The order to shipping process is quite smooth.

What is their service like?

No doubt, they provide the best help and support. Their customer service is top notch. Before I ordered my first purchase, I sent them emails inquiring about the product and its delivery, they responded in time and were quite friendly. They sent a personalized handwritten note with my order which was a nice touch too.

I also noticed that the product that was delivered to me had slightly more content. I weighed the Kratom that I had ordered; there was a bit more in the bag. I also got a sample of another strain of Kratom with my order. They send free samples to all customers.

I must say I am in love with their services!

So, what are you waiting for?

It is quite hard to find any fault or negative points in related to the Kratom Syndicate. I can wholeheartedly recommend this vendor to all, as they sell the finest and best quality of Kratom and its alternatives. You can also buy measuring scoops and Professional high precision digital scale to measure the dose of your Kratom. I must say I totally loved their customer care and everything on their website.

The site map on their website helps you find the products easily. Also, everything on their website is customer friendly. So go for The Kratom Syndicate when purchasing high Kratom and its alternatives.

The post An Honest Review of The Kratom Syndicate – Trusted Kratom Vendor appeared first on Kratomguides.com.

Kava is one of the most powerful options to Kratom known. Kava is a herb that produces a calming effect similar to Kratom. It also helps relax muscles and evoke a sense of contentment like that of Kratom. It is prepared in the same way as Kratom i.e. tea. It relieves anxiety, restlessness, insomnia and stress-related chronic pain and muscular spasm. Due to these pharmacologic actions, Kava is supposedly the best alternative to Kratom, and thus it is widely used in many parts of the world as a replacement to Kratom.

How does Kava work similar to Kratom?

Kratom is a psychoactive drug that provides you an active and socially hyperactive effect after consuming small doses, whereas a higher dose creates calming effects, relieves pain and enables you to experience a state of euphoria.

Kratom is also used as an anti-anxiety drug that also reduces stress disorders and helps relax muscles. Different strains of Kratom have different properties, but it is a mood stimulant, sedative, and a pain killer.

Similarly, Kava acts by reducing stress, alleviates pain and serve as an anxiolytic, and at the same time, it serves as a muscle relaxant. It specifically helps reduced muscular tension and cramps. It helps in making one feel light and calm. Thus he/she has better conversations and has a happy mood.

The two drugs are also similar in the method of consumption. Both are found in the pill form. Their leaves and root can be dried to be either chewed directly or to be used in making tea.
However, due to individual differences, we cannot say that Kava replaces Kratom a 100%.

The most important difference is that Kratom acts on opiate receptors while Kava interacts with the limbic system of the brain. Nonetheless, both Kava and Kratom produce almost similar effects, Kava being less addictive compared to Kratom.

What is Kava?

Scientifically called Piper Methysticum, also known as kava kava, Kava Pepper, Ava Pepper, Sakau, Tonga this plant is known for its sedative qualities. It has a traditional consumption as a hypnotic, psychotropic and anxiolytic. It is consumed like alcohol. This plant resembles in producing effects that are similar to that of alcohol, alleviating anxiety, creating a sense of calmness, acting as an analgesic as well as an anti-depressant. It enhances sociability and helps you with your mood swings.

What is Kava composed of?

Kava contains the following bio actives that give it characteristic properties:

• A mixture of six bio actives that are collectively known as kavalactones or kavapyrones (methysticin, dihydromethysticin, kavain, dihydro kavain, yangonin, and desmethoxyyangonin). These are the main active ingredients.
• 12 other lactones
• Small amounts of awaine, pipermethystine
• Derivatives of Kavain known as Flavokavains
• Glutathione

How do Kava works?

Kava works by the following ways:

• Glutaminergic Signalling

The active ingredient Kavain does this.

• GABAergic Signalling

Kavapyrones enhance GABA(A) signaling through other ligands by increasing the number of binding sites. Dihydromethysticin mainly mediates this action. This induces a state of sedation.

• Dopaminergic Signalling

Kava increases extracellular dopamine, but some of its active ingredients can also cause inhibition of D2 receptors of dopamine. Kawain decreases levels of dopamine while dihydro kawain and desmethoxyyangonin increase it.

• Serotonergic Signalling

Isolated dihydromethysticin can increase levels of serotonin while desmethoxyyangonin decreases it.

What effects does Kava produce?

• Kava used as a therapy for Anxiety

Some clinical studies and users on different drug forums and Reddit state that Kava is effective in treating the symptoms associated with stress. It is an herbal remedy for stress, anxiety, and insomnia. The kavalactones in Kava are responsible for operating in the brain via non-opiate pathways. Some studies suggest that Kava is as good as benzodiazepines.

Kava does not produce cardiac or reproductive abnormalities, so it is a preferred drug, but cases of liver toxicity have raised some questions about Kava as the drug of choice of the treatment of anxiety.

• Kava as a remedy for Mood swings

Kava helps in reducing mood swings and increasing cheerfulness like Kratom. It induces a healthier and pleasant feeling. Menopausal women take it to help them with their mood swings without affecting other systems of the body. Some Reddit users have reported that Kava also increases libido.

• Kava as a therapeutic support for Addiction

Kava just like Kratom has a significant value when it comes to therapeutic support of substance abuse. Kavapyrones are responsible for binding to particular receptors in brains that are associated with cravings and addiction.

• Kava promotes better sleep

Kava is the best herbal remedy for inducing sleep and fighting off insomnia like Kratom. Kava has sedative actions as that of Kratom. It helps improve the quality of sleep and the duration of time required to fall asleep.

• Kava helps fight cancer

Flavokawains present in Kava, have anticancer properties. It inhibits the growth of tumor cells present in prostate and also helps in prevention of metastasis. It also boosts the immune system as it possesses anti-inflammatory properties. It also helps combat breast cancer by decreasing the weight and volume of the tumor.

Are there any side effects of Kava?

Kava is hepatotoxic; it should not be used continuously for more than three months. With the continuous use of Kava, there is yellowing of skin, hair, and nails, and it also causes allergic skin reactions in some users. Long term Kava use can lead to shortness of breath, liver issues, scaly rash on the skin, facial puffiness and swelling.

What precautions should I take when consuming Kava?

• Avoid mixing Kava with any prescription drugs.
• Do not drink concentrated extracts of Kava
• Don’t drive after intake of Kava as it has sedative properties.
• If you have liver disease, do not drink Kava.
• Breastfeeding mothers should avoid the consumption of Kava
• Take Kava under the supervision of a health care provider qualified in the field of botanical medicine.
• Do not drink alcohol while taking Kava.

As stated above, the properties and action of Kratom and Kava match to considerable amount, thus it can be said that Kava is the most strongest alternative to Kratom, though users on Reddit report that Kratom is more potent when it comes to analgesic action as well as stimulating mood and increasing mental alertness.

References:

1. http://www.pillscout.com/mood-enhancers/kratom-alternatives/
2. https://www.reddit.com/r/kratom/comments/4kodva/alternatives/
3. https://www.reddit.com/r/kratom/comments/51090y/kratom_users_looking_to_kava_for_a_replacement/
4. https://drugs-forum.com/forum/showthread.php?t=55934
5. http://kratomguides.com/kava-kratom-combination-similarities-differences/
6. http://www.webmd.com/balance/stress-management/tc/kava-topic-overview?page=2
7. http://umm.edu/health/medical/altmed/herb/kava-kava
8. https://draxe.com/kava-root/
9. https://examine.com/supplements/kava/
10. Shimoda LM, Park C, Stokes AJ, Gomes HH, Turner H.Pacific island ‘Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells. Phytother Res. 2012 Dec;26(12):1934-41. doi: 10.1002/ptr.4652. Epub 2012 Apr 4.
11. Sarris J, LaPorte E, Schweitzer I. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Aust N Z J Psychiatry. 2011 Jan;45(1):27-35. doi: 10.3109/00048674.2010.522554. Epub 2010 Nov 15.
12. Ulbricht C,et al Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration . Expert Opin Drug Saf. (2005)
13. Singh YN Kava: an overview . J Ethnopharmacol. (1992)

The post Kava the Strongest Alternative to Kratom appeared first on Kratomguides.com.

Kava is a drug that is used orally for managing stress related disorders and anxiety, migraines and chronic fatigue syndrome, sleep disorders and depression. It is also reported to treat urinary tract infection, uteritis, and menstrual soreness but it has little research evidence.

Kratom, a potent drug used for relieving chronic pain, managing opiate withdrawal symptoms and for recreational purposes is used commonly in different parts of the world. Kratom and Kava are mixed to potentiate each others effects. The mixture of Kratom and Kava is used to get increased relaxation and more efficient relief from pain.

What is Kava?

It is a narcotic tea-like drink that is made from the roots of Kava, having more than 18 kavalactones responsible for producing effects like euphoria, relaxation, and sedation. These kavalactones also help in alleviating anxiety, pain and as anticonvulsants and hypnotics.

The most widespread feelings that one gets due to consumption of Kava include a sense of well-being, calmness, and relaxed mood. Users initially experience a period where they are highly talkative and socializing, but later onward they get drowsy.

What is Kratom?

Kratom has a long history of traditional and medicinal use. The leaves of Kratom are mainly used in treating patients with generalized anxiety disorders, chronic pain, and also help in the withdrawal of opiate. It behaves similarly to opiates as it gets attached to opioid receptors. It can cause severe dependence if consumed in high doses continuously and causes severe withdrawal symptoms.

Kava-Kratom Mixture PROS

Kava and Kratom are often compared because of these drugs exude feelings of relaxation, and relieving anxiety. However, Kratom has more effects that result in boosting mood and calming the mind. Kava causes intoxication and euphoria. Both drugs when used simultaneously create strong effects that include induction of intense euphoria, promoting feelings of contentment, improving alertness, reducing stress.

The pros of using the two drugs together include the following;

• Significant reduction in anxiety
• Intense feeling of well being after being exposed to a stressful environment
• Increase in cognition
• Improves sleep
• Help fight depression
• Enhancement in mood due to stimulation of serotonergic and dopaminergic pathways
• Significant relief from pain

Kava-Kratom Mixture CONS

Kava and Kratom are both responsible for serious health risks, and their consumption has been strictly regulated around the globe. Recently the use of Kratom in the US has been banned for human consumption. Kava, on the other hand, is known for causing severe hepatotoxicity.

The cons of using the mixture of Kava and Kratom include the following;

• Risk of interaction with several other medicinal drugs including diuretics and anxiolytics.
• If combined with alcohol, it can cause liver cirrhosis
• Excessive dosage is responsible for the hepatic and renal failure.

Individually Kava has several side effects that can be potentiated if mixed with Kratom. Dr. Pat Basu, Chief Medical Officer, states that Kava aggravates hepatitis and hepatic diseases. It causes damage to renal glomeruli and thus one can experience bloody urine. The dermatological side effects include dry, scaly yellow skin. One can also experience weight loss and body tremors due to excessive consumption of Kava.

He also reveals the dangers of intake of Kratom, which includes respiratory depression due to excessive sedation, tremors, and hallucinations, psychosis, and delusions. It can also cause mood swings as Kratom effects brain pathways that control mood. It may also cause vomiting and nausea. It reduces appetite causing weight loss.

Mixing the two drugs can have dangerous outcomes that may result in death too if the doses of the drugs are too high. So using the mixture of Kava and Kratom is highly concerning.

How to take a safe dosage of Kava and Kratom mixture?

According to users on Reddit, there are various ways to make the combination of Kava and Kratom supplements. One way is to blend the two drugs with milk and then filter it to remove the residual splintery fibers and chunks of roots. The other method is to take Kratom first on an empty stomach and after some time wash down Kava, and then eat some food, to remove the aftertaste.

One user suggested taking some digestive enzymes after ingesting the mixture of Kratom and Kava. This will help in the digestion of alkaloids, and the effects will show up rapidly. The safe dosage depends on you. You should be well aware of the two drugs individually. You should not just start by mixing the two drugs. Users on Reddit and drugs forum claimed that a safe dosage for Kratom is around 2-6g while the dose for Kava it is 15 to 25g.

It is important that you be careful about the dose of the mixture of Kratom and Kava. Do not mix this stack with any other drugs, including alcohol. Moreover, you should use it in a limited manner so that you do not develop tolerance to it.

If used appropriately, Kratom and Kava mixture could be safe to combine and consume, not everyone will have the same reaction. In case you suffer from any of the side effects mentioned above, you should consult your doctor immediately.

Never take this mixture if you are pregnant or breastfeeding your child. It is also recommended not to take this combination if you suffer from liver related ailments as it can exacerbate the symptoms.

The post Is Kratom and Kava Safe to Mix? appeared first on Kratomguides.com.

The best Kratom Alternatives are the ones that entirely or maximally mimic the effects of Kratom. These effects include stimulation, energy enhancement and at high doses pain killing action as well as sedation. Many drugs show these results, but no such drug is known which shows all the effects that are produced by Kratom. In the list below, you will find drugs that mimic one or two actions of Kratom, yet we call them the best Kratom Opiate alternatives.

Phenibut

Beta-phenyl-gamma-aminobutyric acid, also known as Phenibut has structural similarities to GABA; it happens to reduce anxiety and stress levels as well as boost energy levels. It has tranquilizing effects and thus it can cause sedation. First discovered in the Soviet Union, this drug has found its way as an anxiolytic, and it also benefits in improving sleep patterns and countering fear. Its use in the treatment of alcoholism, asthenia, stuttering and specific vestibular diseases is also becoming common. It causes muscle relaxation and brings about a healthy sense of calmness and well-being.

The drawback of this drug is that it comes with offensive addiction potential and that quitting this drug can result in severe withdrawal symptoms.

Kava Kava

Scientifically Kava Kava is called Piper Methysticum. This drug has several alkaloids that are responsible for the sedative and hypnotic effects. Different strains produce a different type of results. The effects include euphoria, a sense of relaxation, and one becomes more socializing. It also helps in reducing insomnia. Kava helps in alleviating stress and also acts as an analgesic. It serves as a muscle relaxant by reducing muscular tension and cramps. It also helps one with mood swings.

One should be careful while using Kava with alcohol and other medications as Kava potentiates the effects of the alcohol. It shouldn’t be consumed in large doses as it can lead to hepatotoxicity.

Passion Flower

Known as Passiflora incarnata in scientific terms, this vine has been used medicinally for years. It has the action of potentiating GABA system in the CNS, like that of benzodiazepines but it doesn’t cause addiction. It helps with opiate withdrawal symptoms, alleviates anxiety, insomnia, asthma, ADHD, hypertension, chronic pain, seizures and other ailments. It is a remedy for hysteria and conditions related to panic disorder. It can also be used in patients with chronic tension headache as it helps in the relaxation of muscles. It also prevents virility in males who consume significant amounts of marijuana on a regular basis.

The use of passionflower should be avoided for more than one month, and pregnant ladies should abstain from it. Its side effects include dizziness, confusion, altered states of consciousness and vasculitis. It interacts with other drugs and may show up increase calming effects with benzodiazepines.

L-Tyrosine

L-Tyrosine is the precursor of catecholamines which include dopamine, norepinephrine, and epinephrine. These chemicals are present in the brain. Taking L-Tyrosine can influence the synthesis of these neurotransmitters and help in combating stress, in which the levels of these neurotransmitters are depleted.

L-Tyrosine is known to enhance memory and attention. It can be used in patients that have ADHD. It extends wakefulness and improves cognitive performance even in sleep deprivation. Since it helps in the synthesis of catecholamines, it has a role in neuroprotection. It has another form that is  N-Acetyl-L-Tyrosine (NALT). It should be avoided in patients with a migraine as it can exacerbate a migraine by producing tyramines.

As an alternative to Kratom, it can be used to alleviate stress related disorders and to boost mood as it is responsible for increasing levels of dopamine in the brain pathways.

Mucuna pruriens

Also known as velvet bean this drug helps in the improvement of mood as it is a source of L-DOPA (Levodopa) which is a precursor to dopamine and other catecholamines. Dopamine is responsible for motivation and mental alertness.

Other catecholamines like adrenaline and noradrenaline have effects on concentration and elicit flight and fight response. In simple words, Mucuna Pruriens reduces stress and anxiety levels. It uplifts your mood and reduces lethargy. According to users, Mucuna can be safely taken with other drugs that include caffeine. However, the regular use of mucuna is prohibited as it can cause receptor down-regulation or desensitization, which will ultimately worsen your mood. It may also disrupt your sleep as it keeps your brain active. It can also increase your libido and may also increase orgasmic potential in men and women.

Melatonin

A hormone, made by the pineal gland in the brain, helps in controlling your sleep and wake cycles. It is bought as a supplement to treat seasonal affective disorder (SAD), jet lag, insomnia, chronic cluster headaches, etc. It resembles Kratom in a manner that it resolves insomnia. If mixed with Kratom, it potentiates the sedative effects of Kratom.

Taking melatonin doesn’t replace all the effects of Kratom so we can say that it is not excellent as an alternative but it is better than many. Its use is safe in small doses, but its consumption is prohibited in pregnant and nursing women. Its side effects include vivid dreams that could also be nightmares, sleepiness, morning grogginess, hypothermia, etc. If you feel drowsy after consuming melatonin, you should avoid driving.

Imodium

Imodium or Loperamide is used as a medicine to treat traveler’s diarrhea. It reduces the peristaltic movements of the gut, which makes the stool less watery. It is also employed in conditions like ileostomy and inflammatory bowel disease. Loperamide crosses blood brain barrier in small amounts and acts on morphine receptors. It has calming effects according to users on Reddit, but it doesn’t potentiate the effects of Kratom because it crosses the blood-brain barrier in a small amount. Its side effects are severe so the combination of Kratom and Imodium should be avoided. The side effects include dizziness, drowsiness, tiredness as well as constipation. It may also elicit nausea, vomiting and abdominal pain at high doses.

Valium

Valium or Diazepam is a benzodiazepine that helps in alleviating anxiety. It also acts as a sedative and hypnotic. It’s remedial actions and anti-anxiety actions resemble that of the Kratom. Valium is also used to treat alcohol withdrawal symptoms, and it is a potent muscle relaxant and an anti-seizure drug. Valium can be habit-forming, causing addiction. Combing valium with kratom enhances mood and helps combat with stress related disorders. The combination also gives euphoria and higher doses cause sedation. Thus it can be rightly said that valium can replace the sedative and euphoric effects of Kratom.

Avoid the use of valium if you have myasthenia gravis, liver disease, glaucoma, breathing problem, apnea or if you are pregnant or nursing women. Depressed persons with suicidal thoughts should also avoid the consumption of Valium.

Vitamin B6 Capsules

Vitamin B6 capsules are taken as a supplement. This vitamin is required to synthesize dopamine from L –Tyrosine. When dopamine levels are depleted or when there isn’t enough vitamin B6 and tyrosine to synthesize it then a person experiences depression. Kratom and vitamin B6 act as anti-depressants. However, some users on Reddit and drug forums were of the view that if you take vitamin B6 along with Kratom, you might suffer from panic attacks, tremors, and dizziness. Others claimed that it had almost no effect, while few said that Vitamin B potentiates the effects of Kratom. It is known that vitamin B helps you in counteracting headache and nausea. It also reduces stress levels and makes one happier and induces a sense of relaxation and calmness.

Ginseng

Known as Panax quinquefolius, Ginseng is a drug with a potential for medical use. It has proven to improve mood and reduce stress. It enhances mental function just like Kratom does. It improves performance in people with Alzheimer’s disease. It also improves cognitive performance. It also helps patients with ADHD.

Ginseng is a known anti-inflammatory drug and also has anti-allergic properties that can improve conditions like rhinitis and other upper airway inflammatory diseases. It also helps in weight loss as it boosts metabolism. It also treats sexual dysfunction and improves libido. It has used in promoting immune system, improving lung functions, etc. It has certain side effects. It may cause insomnia and menstrual changes, headaches, and dizziness, etc. When mixed with Kratom it energizes and relaxes one. It also boosts energy and produces euphoria. It can rightly replace Kratom as it enhances mood and causes a sense of well-being.

You can consider the above mentioned Best Kratom Opiate Alternatives in case you do not have access to Kratom, or it has been banned in the place where you are living.

References:

• http://opiateaddictionsupport.com/how-to-use-passion-flower-for-opiate-withdrawal
• http://www.smokableherbs.com/passion-flower/
• https://drugs-forum.com/forum/showthread.php?t=169908
• http://www.choosehelp.com/topics/complementary-alternative-therapies/passionflower-to-treat-opiate-withdrawal-symptoms
• https://www.reddit.com/r/KratomKorner/comments/3iep4w/kratom_and_nalt_nacetylltyrosine/
• http://johnfawkes.com/ten-unorthodox-alternatives-to-caffeine/
• http://www.bluelight.org/vb/threads/346960-Kratom-Tyrosine-First-time-great-alternative-to-regular-stimulants-entactogens
• http://www.consciouslifestylemag.com/mucuna-pruriens-velvet-bean-herb/
• http://www.bluelight.org/vb/archive/index.php/t-469001.html
• http://www.pillscout.com/supplements/mucuna-pruriens-velvet-bean-can-uplift-mood/
• https://drugs-forum.com/forum/showthread.php?t=47979
• https://www.reddit.com/r/kratom/comments/28l801/anyone_try_kratom_and_melatonin_together/
• http://www.webmd.com/sleep-disorders/tc/melatonin-overview#1
• http://www.smrv-journal.com/article/S1087-0792(04)00060-7/abstract?cc=y
• https://drugs-forum.com/forum/showthread.php?t=46890
• http://www.bluelight.org/vb/threads/405317-Loperamide-kratom-Experienced-Potentiating-kratom
• https://www.reddit.com/r/kratom/comments/4wqb0y/imodium/
• http://www.webmd.com/drugs/2/drug-11084/imodium-oral/details
• http://www.selfgrowth.com/articles/valium-and-kratom-comparing-two-anxiety-treatment-options
• https://www.reddit.com/r/Drugs/comments/2t03k9/kratom_benzos/
• http://www.bluelight.org/vb/threads/527884-Kraton-Valium-combo
• https://www.drugs.com/valium.html
• http://www.bluelight.org/vb/archive/index.php/t-607680-p-11.html
• https://www.reddit.com/r/kratom/comments/4n3rkl/my_guide_to_use_kratom_effectively/
• http://www.quitkratom.com/supplements-used-while-quitting-kratom/#more-74
• https://www.reddit.com/r/kratom/comments/2tki8j/ginseng_as_potentiator/
• https://draxe.com/ginseng-benefits/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/

The post 10 Best Kratom Opiate Alternatives appeared first on Kratomguides.com.

Akuamma seeds or Picralima Nitida is an herbal medicine used in different part of Africa as a pain killer. The seeds contain various types of alkaloids which include akuammine and pericine. These alkaloids possess skeletal muscle relaxant, anti-inflammatory, anti-oxidant, anti-diarrheal, antimicrobial, antipyretic,  antiplasmodial and antiulcer activities.

Akuamma seeds resemble Kratom in a way because its alkaloid akuammine is related to mitragynine and yohimbine. Studies reveal that Akuamma seeds can be employed as a remedy for fever, hypertension, jaundice, dysmenorrhea, malaria and gastrointestinal disorders. These seeds are crushed and taken in powdered form, but they have a very bitter taste so usually they are capsulated and sold under the name Picap. The powdered form of seeds can be mixed with food too.

Alkaloids Present in Akuamma Seeds

The two main groups of alkaloids are Akuammine and Pericine. Akuammine acts on delta and kappa opioid receptors.

Akuammidine

It is the primary alkaloid found in the seeds. Structurally it is related to kratom, and it shows the greatest affinity for kappa receptors, making it kappa agonist at opioid binding sites. It has threefold action as a skeletal muscle relaxant, hypotensive action, and local analgesic action. It also has sympatholytic effects.

Akuammine

It is an antagonist at mu receptor. It is a sympathetic system agonist. Its effects resemble that of cocaine. It inhibits intestinal motility and shows a fall in blood pressure. However, at higher doses, it shows hypertension.

Akuammicine

It binds strongly to the kappa opioid receptors.

Pseudoakuammigine

It shows analgesic and anti-inflammatory actions. It acts as an indirect competitive parasympathomimetic. At small doses, it excites the Central nervous system, respiratory system, nervous system, and enhances muscle contractility; at high doses, it causes depression of all these systems.

Akuammigine

It is an antagonist of adrenaline and shows the antiadrenergic activity of the heart, vessels and regulatory center of the circulatory system.

Pericine

It binds to mu-opioid binding receptors. It shows convulsant effects.
Other alkaloids include Picraline, Picraphylline, Picracine, Picranitine, Burnamin and Desacetylakuammiline.

Positive Effects of Akuamma Seeds

As a pain killer

Akuamma seeds are known for their analgesic action. According to users on Reddit and various drug forums, they have been using the seeds to alleviate pain that is caused by Lupus erythematosus, fibromyalgia, arthritis, and migraine. According to them, that it’s a better alternative to opiates as it doesn’t cause withdrawal symptoms and has little addiction profile. Moreover, it’s a natural solution, so it has fewer side effects. Taking two seeds daily has helped a lot of patients fight pain.

In different hospitals of Ghana, the seeds are sold under the brand name ‘Picap’ as a pain killer, and studies prove that it has potential analgesic activity. Physically active people can take the seeds alone for painful, sore muscles.

The best part about Akuamma seeds is that they act very quickly. The effects are visible within 15 to 30 minutes. However, users claim that the effects are not as strong as Kratom, but it helps a lot.

Sedation

One of the positive effects that are caused by Akuamma seeds includes sedation. For all those who are suffering from sleep disorders like insomnia and nightmares, akuamma seeds have proved fruitful as it has the sedative activity. Once taken before sleeping, it gives the best and most peaceful sleep. According to users, the calming effects appear within an hour, and the seeds have helped users with anxiety, pain, and stress to achieve peaceful sleep.

Produces a sense of relaxation

These seeds are known for reducing stress levels and providing an overall sense of well-being. The seeds have helped many users who face panic attacks and anxiety. When this drug is taken, it helps in relaxing the mental state and produces calmness.

Anti-parasitic action

Akuamma seeds are known for their anti-parasitic action. They specifically act against Trypanosoma, which is a protozoon with a single flagellum. It causes diseases like African sleeping sickness, Leishmaniasis, and Chagas diseases. According to a study ‘J Ethnopharmacol: 1989 May 25: 263-8’ Akuamma seeds have a trypanocidal effect, but its pharmacology is unknown as yet.

Anti-malarial action

Picralima nitida seeds and other parts of fruit and stem bark have been investigated in vitro for antimalarial action. The seeds showed inhibitory activity against the resistant strains of Plasmodium such as Falciparum. Two alkaloids akuammine, and alstonine are important in the therapy of malaria Thus it is considered as a potential antimalarial drug.

Anti-diabetic

One of the alkaloid ‘Akuammicine’ present in the seeds is demonstrated to have anti-diabetic properties. The alkaloid promotes the uptake of glucose into the cells thus reducing plasma levels of glucose, like that of insulin.

Adverse effects of Akuamma Seeds

Bitter flavor of seeds

The worst thing that we know about Akuamma seeds is that it has a very bitter taste. It is even worse than that of Kratom. You won’t like taking the seeds directly because most probably you will vomit or you may feel nauseous after the intake of seeds. Chewing the seeds is out of the question. Users reported that since they are bothered by the taste of the seeds they usually grind the seeds in the blender, then add some turmeric powder and place it in capsules. This way they can avoid the bad taste of the seeds.  If you take it in the powder form or tea, you can add sweetener to offset the bitterness.

Headache

If a larger dosage such as 2 grams or more of Akuamma seeds is taken, then there are possibilities that you might experience a headache, but usually, at such large dose, you will also be sedated.

Hyperkalemia and hypernatremia

The seeds can cause ion regulatory disturbances which include slightly increased levels of Potassium and Sodium in the plasma, but it is not significant enough to cause any problem.

References:

1. Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae). – Menzies JR, Paterson SJ, Duwiejua M, Corbett AD; Department of Biological Sciences, Glasgow Caledonian University, UK.
2. Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors.  – Lewin G, Le Ménez P, Rolland Y, Renouard A, Giesen-Crouse E. Journal of Natural Products. 1992 Mar
3. http://www.allaboutheaven.org/suppression/66/115/picralima-nitida
4. https://www.reddit.com/r/kratom/comments/4i0ncl/akuamma_seed_capsules_available/
5. http://krampusbotanicals.com/akuamma-seed-reviews/
6. http://cyberleninka.ru/article/n/some-untoward-effects-associated-with-the-use-of-the-biopreparation-from-picralima-nitida-seeds-extract-as-antidiabetic-agent
7. http://www.alternativeprime.com/akuamma-seeds/
8. http://www.bluelight.org/vb/threads/370536-Akuammine-and-other-Indolic-Opioids

The post Akuamma Seeds – Positive and Negative Effects appeared first on Kratomguides.com.

Depression and anxiety issues are distinctive, however, individuals with gloom frequently encounter manifestations like those of an uneasiness issue, for example, nervousness, irritability, and problems while sleeping or concentrating. Be that as it may, every confusion has its causes and its own particular enthusiastic and behavioral side effects. So both falls in the same classification and because of which both have same supplements for healing. If you seek the on-spot  remedies for these depressive disorders, Kava, Kratom and Passion Flower are among the top 10 supplements for anxiety and depression. For further information, take a look below:

• Kratom

Kratom is a tropical tree usually found in southeast Asia. It belongs to Rubiaceae family which also includes other plants like a coffee tree. It is used as an herbal drug and also as stimulating agent uplifting mood and enhancing energy levels of the mind. Kratom is used for pain relief and antidepressant ailment. It consists of compounds that are psychoactive or account alerting opioid. It is used to control the withdrawal of any drug addictions like alcohol. It helps to monitor the craving for medicines. It may be employed in the form of dry leaves, smoke or powdered form of gum.

Kratom is great for depressive patients because its alkaloid compounds directly attach to the opioid receptors of the patient’s brain. The alkaloid ‘mitragynine’ does the trick! After consuming Kratom, the patient or the normal user feels boosts of energy, better concentration skills while the overall perspective about life becomes positive.

• Kava

It is also a plant whose roots are used to produce drinks which act as anesthetic sedatives and euphoria. It is very effective against depression, stress, insomnia and digestive disorders. Its antispasmodic qualities release nervous tension while it aids in feeling relaxed. By taking its high dose, the user may suffer from kidney or liver problems.

Kava releases fatigue and boosts the energy levels. Kava is also an anti-inflammatory herb and is present in the supplement pro-vax.

• L-Theanine

Its scientific name is Gamma-methylamino -L-glutamic acid and commonly called as L-theanine. It is constituent of green tea. As tea is the most widely used drink all over the world, L-theanine is very helpful in relieving stress, hence. It may also have immunologic attributes. L-theanine effects cardiovascular system and prevents cancer in the long run.

• Lavender

Lavender is the common name of the flowering plant Lavendula. It belongs to the mint family. Its scent lowers the blood pressure and enhances pleasing effects and helps the user feel relaxed and calm. It is a volatile oil with a fragrance which relieves anxiety as well. It is also used for gastrointestinal distress, insomnia and “nervous stomach”.

• Passion Flower

Passionflower (Passiflora incarnate) was utilized customarily as a part of the America and later in Europe as a perfect herb for anxiety, sleeping disorders, seizures, and hysteria. It is still utilized today to treat anxiety and sleep deprivation. A couple of relevant studies have tried passionflower as a treatment for anxiety or sleep deprivation, however since passion flower is regularly consolidated with other quieting herbs, it is hard to tell what impacts passion flower has all alone.

A)    Plant description

Local to southeastern parts of the Americas, passionflower is presently developed throughout Europe. It is an enduring climbing vine with herbaceous shoots and a sturdy woody stem. As per legends, passionflower got its name since its crown resembles the crown of thistles worn by Jesus amid the torturous killing. The passionflower’s ready natural product is an egg-formed berry that might be yellow or purple. A few sorts of passionflower are eatable.

B)    Parts used

The above-ground parts (flowers, leaves, and stems) of the passionflower are used for medicinal purposes.

• Chamomile

The way that chamomile decreases anxiety and anti-depression, this herb was solidified by a clinical study at the University of Pennsylvania, School of Medicine. This study was conducted in 2009, yet its information and discoveries were re-researched and affirmed a year ago.

The scientists enrolled 19 individuals determined to have tension with discouragement, alongside 16 people who were analyzed as having a past filled with nervousness and misery. These groups were considered on the side of a control gathering of 22 individuals who had no nervousness or depression – past or present. The results were found hence!

• Cannabis

The cannabis plant has historically been utilized worldwide to treat disease and health conditions. Cannabidiol, or CBD, is the cannabis exacerbate that has found to have significant benefits for treating individuals with depression. CBD-rich cannabis can be used for patients looking for cures to inflammatory diseases, general pain, and anxiety. CBD does not make people feel “stoned” or “high,” and can counteract the uneasiness driven inclinations of THC. It is a noteworthy component, making up to 40 percent of the plant’s concentrated and has a more extensive health advantage than THC.

• Skullcap

Skullcap is the anti-nervousness solution for individuals who encounter anxiety alongside eagerness, muscle pressure, and jaw freezes. If you tend to thrash around in bed or on the off chance that you have an inclination that you can only unwind when you’re out strolling (yet sitting still makes you need to bounce out of your skin). If you have a craving for “climbing the dividers” when you’re stuck inside amid an episode of uneasiness, skullcap can help you to loosen up your nervousness, as well as the strong pressure and restlessness. Skullcap is compelling in tea or tincture (tincture is a herb removed from liquor), however, if you can endure small measures of alcohol, 20-40 drops of the tincture (for a 150-pound individual) will be the best cure.

• Ashwagandha

Ashwagandha is an Ayurvedic herb from the roots of Withaniasomnifera, a plant in the nightshade family. It has long been used for hundreds of years for its ability to help the body deal with anxiety and depression. It has also been used to boost the immune system, improve memory and to promote overall wellness.

• Hypericum Perforatum

Hypericum was known to be a powerful treatment for anxiety by Hippocrates. This old Greek doctor utilized Hypericum as a treatment for “anxious unrest”. Hypericum has been utilized for more than 2400 years as a treatment for uneasiness, stress and rest aggravations. Cutting edge therapeutic research has indicated unmistakably that Hypericum is as powerful as medicinal antidepressants, for example, fluoxetine for treating gently to direct discouragement. Be that as it may, not at all like antidepressants endorsed by specialists, the symptoms from Hypericum are few and mellow. Hypericum is accessible without a solution, making it an available and an open homegrown drug!

The Best Supplement of all!

If you are confused between the listed choices, the safest bet is Kratom! No joke. The reason of its reliability lies in the results it provides to each user across the globe. Not only does it treat depression and anxiety directly, but also boosts energy levels. It recovers a healthy appetite, enables the user to see the surroundings in a positive manner while helping the user socialize once again. The best part? Zero side effects!

While it is perfect for your brain, it is essential for your overall health as well. The underlining factor is how and when you use it. If you are sick of seeing your loved one suffering from anxiety and depression, you know what to do!

There may be many other supplements available today, but these above-mentioned supplements are best for use. They are not only recommended by the researchers but also the doctors and health practitioners. If you want the perfect, on-spot cures for anxiety and depression, these are your list of answers.

The post The 10 Natural Supplements for Anxiety and Depression appeared first on Kratomguides.com.

When you are taking a medicine or some drug to elicit a response, it is important that you consider the appropriate doses, but more importantly, you should be aware of the methodology of taking the drug. Taking drugs IV can cause quick and severe effects on heart and brain provided the drug crosses the blood-brain barrier. Taking drugs orally might not show the desired response, may be due to extensive first pass metabolism or interaction with the gastric juice, etc. before absorption. This article will describe how to take Akuamma seeds, and it will also highlight the correct dosage with their respective effects.

Akuamma seeds, being a natural pain killer are sought out by many people who are suffering from chronic pain and are not getting an analgesic effect from the use of opiates, NSAIDS, etc. Since the drug is primarily used as an analgesic, a standard dose can’t be mapped out because everyone isn’t suffering from the same kind of pain and everyone doesn’t have the same pain threshold. However, for the convenience of readers, reviews from different drug forums, including Reddit have been added into the article to give you a better insight into the experiences of other people and how you can relate them to yours.

How to take Akuamma Seeds?

You think you have tasted bitter by tasting Kratom? You are mistaken. Akuamma seeds are way bitter than Kratom. Most people prefer to take Akuamma capsules as the bitter flavor is almost unbearable. Those who take it in the form of powder, add a sweetener or make it with tea. Some users take Goji berry along with it to reduce the bitterness. You can purchase the Akuamma in the form of raw seeds, ground seed powder as well as capsules. You can use an excellent coffee grinder to crush the seeds and then measure out the correct dose for yourself.

Never use a teaspoon as a scale to your dose. Always weigh the amount of powder that you will be taking. Use an accurate digital scale and then find the best capsule size for yourself. You can have vegan capsules too if you are allergic to the other ones. Fill the capsules according to the dose that you ingest. This way you can have a stock of pills readily available to you.

Some users prefer the toss and wash method while others even chew the seeds, but it has been reported that eating the seeds can cause severe nausea and vomiting. To avoid this, you can toss the required dose in a piece of the toilet or some rolling paper, twist it up and cut off the excess paper. Then swallow it. Avoid drinking too much water after it because if you burp you will get the bitter taste all over again in your mouth.

How to prepare purified alkaloids from Akuamma seeds?

When using Akuamma seeds as an antiprotozoal drug, you can follow this method to take medicine. This process ensures that you get the purified form of the alkaloids. It comprises the following steps.

1. Pulverising picralima nitida plant
2. Use a solvent to extract the material. Dry it and then re-extract the dried material with a different solution.
3. Extract a fresh sample of Akuamma with boiling water.
4. Filter and concentrate the boiling water solvent extracts under reduced pressure.
5. Concentrate the dried extract now to obtain the gum. Re-extract the Akuamma gum with an aqueous acidic HCl solution.
6. Next, filter the acidic extract and make it alkaline to a pH of about 9 using NaOH solution.
7. Extract the alkaline solution using dichloromethane, concentrate it and then dry it under reduced pressure to obtain an alkaloid fraction.
8. Next, separate the alkaloid fraction using liquid chromatography-mass spectrometry to obtain purified alkaloids that can be employed in the treatment of various diseases.

What is the correct dosage of Akuamma seeds and how long does the effect last?

Average reported dosage by many users is around 250mg-500mg. This is almost equal to 1-2 seeds. If measured by spoon, this equal to 2/3rd of a teaspoon. The extract usage is considerably less overall. Users state that an ounce powder usually lasts 20-30 days, but this totally depends on the usage of the individual.

To kill severe pain, people go for a dose as high as 2-4 grams, and according to some users, they experience analgesic effect at a high dose of 6 grams. However, if you are new to this drug, it is recommended that you start with a little dose and then work your way up slowly to identify the proper dosage for yourself.

Users on Reddit reported that effects last for 3-4 hours maximum.

At what doses will I experience side effects?

Side effects start appearing with continuous use and high doses. Though Akuamma seeds have been accepted as a safe pain killing regimen, however, it must be mentioned that it is a sedative and high doses exceeding 6-8 grams can cause the depression of the respiratory center in the medulla resulting in a coma which can even prove fatal.

At a dose of 2 grams and higher, you will most probably experience headaches.

What is the best option for me?

Akuamma Seeds: Ground the whole seeds and use the toss and wash method. One seed is usually equal to 2/3rd of a spoon. Though it isn’t a pleasant way to ingest seeds, this approach is the most efficient and provides fast relief from pain and gives a sense of well-being.

Akuamma Seed Capsules: This is taking the Akuamma seed powder. One capsule is equivalent to 1 seed, and around three tablets provide the best analgesic effect. If you need a quicker relief, you can make a hole in the capsule or open it to toss and wash.

Akuamma Seed Tincture: For faster and fuller relief you can take few droppers full. It doesn’t have long lasting effects, but it gives the fastest way to pain relief.

The post How to take Akuamma Seeds and its correct dosage? appeared first on Kratomguides.com.

Kratom is legal in many states of the US, however; people are dubious about its legality. This is the reason why they are searching for a good Kratom alternative which is not just legal but equally potent. Luckily, Mitragyna Javanica discovered as a useful replacement, but it is not as powerful as Kratom. Before moving on, you should know about Kratom, its essential uses and relation with Mitragyna Javanica.

Kratom is a most beneficial tree found in Southeast Asia (Malaysia, Thailand, Borneo, Indonesia and more). Botanical name of Kratom is Mitragyna speciosa. Its leaves are used for making herbal medicines by Southern Asian people. Kratom is useful for:

• Diarrhea
• Opiate addiction
• Restless leg syndrome
• Arthritis
• Fibromyalgia

On the flip side, Mitragyna Javanica belongs to the same family as Mitragyna speciosa, from where Kratom is extracted. That’s why it’s considered as a substitute for Kratom.

What Is Mitragyna Javanica?

Mitragyna Javanica is also present in Southern Asia. Because of its close relation to Mitragyna speciosa, Mitragyna Javanica is visually quite similar to Kratom. Both are sturdy and tall with broad leaves. However, inside of leaves is entirely different from one another. When it comes to Mitragyna Javanica uses, the herb is not as much effective as compared to Kratom. But, it’s still rated as one of the best alternatives to Kratom.

Alkaloids present in Mitragyna Javanica

Mitragynine is the most active alkaloid in the Kratom is useful for enhancing mood and relieving pain. On the other hand, this alkaloid is not present in Mitragyna Javanica. Instead, it contains Mitrajavine as an alternative, and it has plenty of 3-isoajmalicine as well. Unfortunately, many people don’t know about it because of no pharmacological tests were taken on Mitrajavine.

Comparison: Kratom v/s Mitragyna Javanica

Despite the fact that Kratom and Mitragyna Javanica are somewhat related to each other, no one could prove that Javanica is better than Kratom because most people are not aware of it. What is the essential difference between both of these herbs? Which one is stronger “Kratom or Mitragyna Javanica? Do they have same benefits? To know all the answers, continue reading this!

Mitragyna Javanica is perfect for those who are looking for a mild substitute of Kratom. Another big reason to buy it is that it is legal everywhere. People don’t face any issue while buying it. In addition, Mitragyna Javanica is not a strong antidepressant as compared to Kratom. It produces less dramatic stress relief.

Kratom also can reduce high blood pressure, however; this property is absent in Javanica. Both these herbs are much different when it comes to their function. In short, Mitragyna Javanica is not an entire substitute of Kratom. The only reason people use it as an alternative is that Kratom is not legal in many countries, unlike Javanica.

Is Mitragyna Javanica legal in the US?

In 1935, Thailand banned Kratom and many states in the US followed the same. That was the reason why public started searching for an alternative for Kratom and found Mitragyna Javanica. However, most of them were not happy with it because Mitragyna Javanica is not as promising as Kratom. Moreover, the best thing about Mitragyna Javanica is that it is legal and accessible everywhere. People of the US are getting to know about the uses of Kratom and its mild alternative – Mitragyna Javanica. So, more people are interested in buying it these days.

Mitragyna Javanica dosage and how to use?

To prepare tea, a hot cup of water requires around 10-20 grams of Mitragyna Javanica. Let it steep for almost 30 minutes. It is said that, Mitragyna Javanica doesn’t taste as intense or bitter as Kratom. So, it is more pleasant to have it instead! You can also fill 1 to 1.5 grams of Mitragyna Javanica in capsules for real stimulating and sedative effects.

Do your experiment with Mitragyna Javanica dosage in powder form. 1-2 grams is good for the beginners, and then you can gradually increase it to get your desired effects.

Users reviews of Mitragyna Javanica

User 1: I had taken two teaspoons of powdered Javanica. Its taste was not unpleasant. As a comparison with Kratom, it was less bitter. In addition to this, Mitragyna Javanica powder has the property to clump together. Whereas, Kratom powder is smooth and doesn’t form any clumps. After 3 hours of its consumption, I didn’t feel any nausea or a headache. Not feeling nausea is indeed a good thing! In short, it was a good experience for me.

User 2: Mitragyna Javanica is tasteless. I was not able to judge what it tasted like. Surely not bitter nor intense. But, because of its less painful nature, unlike Kratom, I realized that it doesn’t contain alkaloids. Mitragyna Javanica may work better for those who never tried Kratom before because they wouldn’t be able to compare these two. The bottom line is, this thing is surely not Kratom in any way!

Where can you buy Mitragyna Javanica?

Mitragyna Javanica can be bought from online vendors no matter wherever you live. This herb is easily available in different online stores. You can simply Google particular websites by pasting the keyword “buy Mitragyna Javanica online.” Relevant results will appear, and you can choose from the ones that suit your logistics.

The verdict

Mitragyna Javanica can’t replace Kratom for so many reasons, but it is good for those who want a mild substitute for it. Mitragyna Javanica is readily available and legal. Kratom, on the other hand, is illegal in some states. Mitragyna Javanica is available online, and it can be found in stores too. Without trying it, you can’t see its worth.

The post Mitragyna Javanica – The Best Alternative To Kratom appeared first on Kratomguides.com.

Kratom and Adderall combination is one potent combination! The two CNS stimulants act simultaneously to enhance mood, motor activities, cognition and help in achieving unachievable! The combination of Adderall and Kratom means you are double dosing yourself with the strongest CNS stimulants available! Yes, it has all the pros you could think of, but the mixture is deadly dangerous! To know more about this mixture let’s have a look at the drugs individually and then their combination, along with pros and cons.

What is Adderall?

Adderall is the brand name of amphetamine, a drug used in treating attention deficit hyperactivity disorder, narcolepsy, and overeating. Adderall is a combination of amphetamine and dextroamphetamine which acts as central nervous system stimulants. Though it is a very useful drug, its therapeutic usefulness is limited due to psychological and physiological dependence similar to those with cocaine, and with chronic use, there are chances of developing tolerance to the euphoric and anorectic effects.

How does Adderall work?

The effects of amphetamine on the CNS are indirect. It acts by elevating the levels of catecholamines in the synaptic spaces. It achieved by releasing the intracellular stores of catecholamines. It also inhibits monoamine oxidase, the enzyme responsible in degenerating epinephrine and norepinephrine. Once this enzyme is inactivated, the neurotransmitter shows longer action.

Amphetamine also enhances the release of dopamine. It does so by stimulating the entire cerebrospinal axis, brainstem, and medulla. This leads to increased alertness, decreased fatigue, depressed appetite, and insomnia. At higher doses, psychosis and convulsions can ensue.

What is Kratom?

Composed mainly of the alkaloid mitragynine, Kratom acts as a painkiller, a stimulant, a mood booster and as an anxiolytic. The drug is also known for sedative action at higher doses. Previously used as an herbal medicine for chronic pain, this drug is more of a recreational substance now, and its abuse is very common. The topic of its usefulness is quite controversial, and that is why it is banned in many parts of the world, however, we will be focusing on the therapeutic use of the drug for those who suffer from chronic pain and need to take a break from all sorts of opioids. Kratom acts on the mu receptors of opiates to produce its effects. At small doses it enables enhancement of productivity, brings about euphoria and causes a sense of well-being and calmness. At high doses, it causes sedation.

How does Adderall and Kratom combination work?

Adderall and Kratom work in synergy. The two drugs at low doses act as stimulants. Adderall has the effect of producing a sense of energy and enhances productivity while Kratom focuses more on calmness and brings about relaxation. Both drugs produce euphoria and a feeling of contentment.

At high doses, there is variation in the behavior of the two drugs. Kratom induces a sleep-like state and sedates while Adderall causes insomnia.

Reddit users explained in a thread that taking Kratom at night after taking Adderall during the day helps in making one sleep. Instead of taking Xanax that comes with dependence and tolerance, the best option is to take Kratom to induce sleep. However, other users were of the view that since Kratom is a CNS stimulant, it will potentiate the effects of Adderall

Kratom has helped many Adderall users to combat the Adderall crash and also to relieve the anxiety that is caused due to the regular use of Adderall. Drug forum users stated that Kratom and Adderall could act best together only if you find the right Kratom strain for yourself and there is a significant gap between dosing yourself with the two drugs. They explained that taking Adderall during the time to increase alertness and Kratom at night to induce sleep. However, the Kratom strain shouldn’t produce stimulation.

The strains that potentiate the effects of Adderall include Bali, Green, and White vein. On the other hand, red vein strain can be used for the comedown and induction of sleep.

Taking the two drugs together can induce euphoria and enhance focus. Kratom helps in maintaining a good mood and also avoids the depression caused as a side effect of Adderall. Kratom also helps manage pain that is due to skeletal muscle contraction, and it allows you to feel confident and productive without fearing a harsh comedown.

Adderall side effects

Dextroamphetamine and amphetamine may cause side effects, including:

• Nervousness and Restlessness
• Changes in sex drive or ability
• Difficulty falling asleep or staying asleep
• Uncontrollable shaking of a part of the body i.e. tremors
• Headache
• Dry mouth
• Stomach pain
• Nausea and vomiting
• Diarrhea/ Constipation
• Loss of appetite causing Weight loss
• Fast or pounding heartbeat i.e. palpitations
• Shortness of breath
• Chest pain
• Weakness or numbness of an arm or leg
• Seizures
• Mania (frenzied or abnormally excited mood)
• Aggressive or hostile behavior
• Changes in vision or blurred vision
• Fever
• Difficulty breathing or swallowing

Contraindications of Adderall

Adderall is contraindicated in the following cases.

• Anxiety or agitation
• Glaucoma
• Family history of Tourette Syndrome or tics
• Congenital Heart defects
• Heart rhythm disorders, coronary heart diseases, history of myocardial infarction
• Hypertension
• Seizure disorder especially epilepsy
• Mental illness like schizophrenia, mania
• Peripheral vascular disease
• Patients on MAOI’s inhibitors

Adderall and Kratom mixture precautions

• Before taking the two drugs, you should be aware of your mental and physical status.
• Don’t take Adderall if you have taken MAO inhibitor in the last two weeks.
• Monitor the usage of Kratom and Adderall as the combination has a high risk for addiction or abuse.
• Avoid snorting of Adderall as it can cause necrosis of the nasal septum along with severe respiratory irregularities.
• Monitor the amount of alcohol that you drink while taking this combination.

Conclusion

The mixture of Adderall and Kratom is highly dangerous and should be avoided. Both drugs can cause severe dependence and are subject to tolerance. A person who is dependent on Adderall for carrying out day to day activities will take extreme measures to get hold of the drug even if that puts their well-being at risk.

If you take the combination of the two drugs, ensure that you take small doses and taper down the dose in case you want to quit the usage of Adderall. If you stop taking Adderall all of a sudden you can face ‘Adderall crash,’ leaving you to feel sluggish, disoriented and disconnected. Also, you will have temporary symptoms of withdrawal.

The post Kratom and Adderall combination, does it really work? appeared first on Kratomguides.com.

Blue Lotus flower is a beautiful water lily belonging to the genus Nymphaea, also known as Blue Egyptian Lotus, Blue Egyptian Water Lily, Sacred Blue Lily or Sacred Narcotic Lily of the Nile. It is said to be widely used by Mayan and Ancient Egyptian civilizations. The flower is thought to have Godly associations too. The blue lotus plant is known to purify the blood, strengthen breasts and is useful in treating worms, tuberculosis, vomiting, vertigo, fever, edema, dysuria and toxicosis.

What is Blue Lotus and where it originated from?

Blue Lotus flower, scientifically referred to as Nymphaea Caerulea, is a natural sedative originated from the Nile River in Egypt. For more than a hundred decades, the native residents used it on spiritual occasions. The main purpose was to get better consciousness. At the outset of the third century, they introduced it to the conquering Greeks who exported it worldwide. The Egyptians also used it for libido.

What are the uses of the Blue Lotus?

Blue Lotus is said to have psychoactive alkaloid apomorphine and nuciferan as its components. It can be used to treat gastrointestinal diseases. It can also be used in diarrhea and dyspepsia. The reason the plant became popular in Egypt is its primary effects of euphoria and alleviation of depression. Many people also experience a mild stimulant-like effect that encourages socialization.

Blue Lotus also helps in erectile dysfunction, especially caused due to depression. The flower can be used to promote somnolence, anti-anxiety agent and for relieving stress. The flower is used in perfumes. Aromatherapy also recognizes the effectiveness of its oil. The blue lotus flower is said to have ginseng that acts as an anesthetic agent.

Each and every part of the Blue Lotus plant is useful in some or the other way. The leaves of the plant used for burning pains, thirst, hemorrhoids and bleeding from internal organs. The receptacle for the seed cleans the mouth and makes the blood pure. The filaments are aphrodisiac in nature, improve the complexion, help in oral ulcers and eliminate the tendency to abortions. The leaf-stalk helps in lactation. Honey from the lotus flowers is very nutritive and contributes to fight eye diseases.

Several countries use the seed extracts to prepare skin care products as it acts as a natural moisturizer. It is ideal for people with dry, flaky skin. It also prevents recurrence of pimples and acne. Besides skin care, the blue lotus flower also used in hair care products as a conditioner. Menstruation problems can also be solved with the help of the flower extracts. The silent killer diabetes and its complications like cardiovascular disorders can be kept under control with this sacred flower.

What are the Blue Lotus side effects?

Blue Lotus can have mild side effects that prove to be harmless for a majority of the people. However, when taken in large doses, it can lead to hot flashes and mild jittery feeling. It can also lead to hallucinations and hypnosis when taken in excess.

Side effects of the flower are related to its combination with other drugs. On combining it with illegal drugs such as cannabis or prescription painkillers, the individual experiences severe nausea or disorientation.

How to use Blue Lotus?

Blue Lotus can be used in several ways. People have been eating the plant to keep alive that tradition of Lotophagi was eating it in “The Odyssey.” In today’s world, people brew it into tea or add it to different cocktails, wines, and liquors. They boil the entire plant for around 20-30 minutes and then use it.

In addition to ingestion, it can also be smoked. However, make sure that you mix the petals and bulbs as the ingredients spread over both these components. You can even use it as an herbal combination to feel peaceful and euphoric.

5 grams is the starting dosage of the flower extract.

Is it legal to use?

As far as the United States is concerned, it is not a controlled substance. Nonetheless, it has not been accepted for consumption by humans. Though the cultivation, sale, and purchase are considered to be legal, it cannot be sold for consumption. Stores commonly sell incense and weaker teas but they should abide by the regulations. Louisiana is the only state in the entire country that has issued new laws about Nymphaea Caerulea, which are mainly passed to discourage human consumption.

While the flower is globally legal, Russia has banned its usage altogether. It has been done to prevent the scandals of synthetic marijuana.

User experience of Blue Lotus

I came across blue lotus flower for the first time on my trip to Thailand. I was very much fascinated by its medicinal value and the way the residents raved over it. A few years later, I lost my job, and because of that, I became socially aloof. I did not know what to do and severed all connections. I felt blue all the time and stayed upset in the four walls of my house.

Once while surfing the web, I came across an article on Blue Lotus flower and got reminded of the magical effects it has. I ordered the product and started using the petals in my tea. I felt relaxed, and a sense of euphoria took me over, after ingesting it. I reunited with my long lost friends and tried out the resin extract from the plant as suggested by one of them.

I occasionally smoked it in the proportion of 10:1 resin extract according to the customer reviews on drugforum and felt really awesome. I also started feeling good about myself and applied for interviews at several places. My hard work paid off, and today, I have a job. I owe a bit of my success to this wonder flower.

The customer reviews and information shared by them also proved to be extremely helpful to me. Thanks to blue lotus for all the therapy. I feel overwhelmed whenever I look at that beautiful blue flower.

The post Blue Lotus Benefits, Side-effects & How to Use? appeared first on Kratomguides.com.

Many of us are victims of stress which is totally out of control. It is an unwanted friend who never leaves you alone once attached. Are you a sufferer of depression too? Are you fearful to try medicines for their side effects? If yes, there is a safe solution for you. Kava Kava naturally cures anxiety and depression. It is a traditional drink as an alternative to coffee and tea which works like magic. Sounds unbelievable right? This article will help you to know the secret benefits of Kava and how it works for reducing anxiety.

What Is Kava Kava?

Kava Kava also known as simply Kava is a traditional drink of South Pacific region. It is an herbal based formula which has many health benefits for you. It is long associated with to cure sleeplessness, anxiety, and depression yet it might not be suitable for everyone. It has also been a traditional element in various cultural and religious ceremonies. To avail the healthy benefits of it, the information and usage should be made available by everyone.

How does Kava work?

Kava Kava is an extraction from a plant named Piper methysticin (a plant from pepper family) which is used to make drinks. The name of this plant has a literal meaning of intoxicating plant that shows it has some hallucinating effect to makes you feel lighter. In ancient times, it was chewed to gain a temporary relief from tension, stress, and insomnia. Kava for anxiety has roots from history which later on proved to be a natural antidepressant according to medical researchers. Kava is available in the form of the herb, herbal extract, tincture tea and supplements in the form of pill and powder.

Cultural significance of Kava

Many cultural and religious groups prefer a nonalcoholic lifestyle. Yerba mate is a traditional drink in South America. Matcha is a popular similar drink of Japan. For South Pacific region, Kava is the most favorite drink of all times. Communities from Micronesia, Hawaii, and Polynesia share a common festive drink made of Kava plant root for thousands of years. The taste is unique, makes your mouth numb and creates a relaxed feeling similar to a modern day spa treatment. According to a research contributed on the Journal of Clinical Psychopharmacology, the Kava helps for anxiety treatment since all the tensions are vanished by the last sip, and no side effects are caused since it’s an herbal product.

Kava – The natural Valium

The active ingredients of Kava are certain phytonutrients called kavalactones. These lactones attach to the receptors which are linked with mood swings, cravings, and addictions. Thus, the potential for abrupt behavioral changes is reduced to the minimum. It is even beneficial to overcome the harmful addictions of alcohol, tobacco, and drugs. For its supportive and relaxing help, Kava is often called as natural Valium. It is part of daily intake for many people who use it in tea. It contributes to balance the hormonal elevations and behavioral changes in them.

Mental support by Kava

Many research groups worked to study the effective dosage for treating depression, stress, and anxiety by Kava. Kava dosage for anxiety has a mixed opinion, but a majority of the scientists agreed to an average intake of 210-240 mg.

However, a research group of Complementary and Alternative Medicine Guide from Maryland suggested it to be 300mg. Kava makes you drowsy, so the recommended dose is never higher. Also, it is advised to be taken in the evening so that it doesn’t hinder to the routine of any user. A misunderstanding with kava is that it elevates you in no time and disables you for doing concentration required tasks e.g. driving, which is not true.

A research published in Traffic Injury Prevention Journal (2013) shows that it doesn’t hider with a person’s mental abilities while driving. Kava, being the nature’s gift to us works slowly. Some people feel relaxed even after the 2-4 dose and others take a long time to feel a difference.

Is Kava safe to use?

The best thing about Kava is that it doesn’t interfere with your reaction time which is a common drawback of other antidepressant medicines.  A research study from 2015, published in Trails journal proved it to be a safe first line of choice for the treatment of general anxiety disorders (GAD). There are some side effects associated with standard antidepressants which are no more threatening if they are replaced with Kava Kava. Depression patients are often characterized as low self-esteem and low sex drive surfers.

A clinical study from University of Melbourne (2013) proved Kava to be aphrodisiac which increases the libido in its users. It shows that Kava is beneficial for boosting sex drive along with reducing stress.

Availability and warnings

Kava use for anxiety is banned in most of the countries due to rawness regarded with an extra high amount of toxicity. This toxicity is dangerously harmful to the liver and because of this, its usage is controlled and banned in some areas of UK, France, USA, Australia, Canada, Germany, and Switzerland. But only the raw form of Kava is banned, it is easily available as a dietary supplement in all commercial markets.

Kava’s dosage for dietary supplements was carefully determined. It is recommended to discuss the doctor before selecting a dosage for yourself because there are several situations where it should not be used.  Pregnant women, breastfeeding mothers, underage children and liver patients are never allowed to use it. Since Kava has active chemicals in it, there are a lot of other chemicals to which it can interact and harm the body, for this reason, it is not advised to be taken with any other medication.

The bottom line

Even with a ban on its sale, it is popular in tribal communities, and it barely experiences any health concern. There is a particular recipe to use this plant in drinks which are less harmful as highlighted by the researchers. Even after all studies, Kava is a popular choice for a study to determine the toxicity levels of its parts and the methods to expand its medicinal values. As a traditional drink and dietary supplement, the accurate measure is to watch its dose along with the health status of the user. It should not be mixed with other supplements, antidepressants, alcohol or drugs. In the case of any side effect, immediate rush to the health provider is advised.

The post What is Kava Kava used for? How well does Kava work for anxiety? appeared first on Kratomguides.com.

Sceletium or Kanna is one of the most traditional herb used for mind-alteration, also known as Sceletium Tortuosum. It is thought to have a profound impact on how human consciousness has evolved. It is naturally available and commonly consumed as a mood booster.

What is Kanna (Sceletium) and where has it originated?

Sceletium is a succulent shrub belonging to the ice plant family. The San and Khoi people from South Africa are known to have used Sceletium to subdue their hunger and thirst in tincture form. Besides, it was also used to relieve pain and elevate their mood. Pastoralists and hunter-gatherers also used the plant for mood alteration during prehistoric times. Jan van Riebeeck is known to have written the oldest account of its usage in the year 1662.

A fermented and dried preparation of Sceletium is known as Kanna or Kougoed. It means chewy things or something to chew, and it has been utilized as a very safe and advantageous inebriant since the prehistoric times. Kanna is chewed, prepared into tea and even smoked or snuffed sometimes.

What are the uses/benefits of the Kanna (Sceletium)?

Kanna is truly a natural wealth and a botanical marvel. It is a wonderful herb facilitating bodily and mental relaxation. Obsessive thinkers can benefit a lot through Sceletium as it calms down the thought process and enables expression of thought, speech and emotion. All in all, it is a great healer.

Sceletium stimulates the function of serotonin in the brain far better than L-Tryptophan, 5-Hydroxytryptophan, and Griffonia. What makes it superior to these agents is that it does not lead to drowsiness commonly experienced while using the precursors of serotonin.

All the medicines available to fight depression are either Selective Serotonin Re-uptake Inhibitors or Serotonin-Dopamine Re-uptake Inhibitors. They work by developing serotonin in the brain, but it leads to unwanted side effects. The pharmacological action of Sceletium is as a Serotonin Releasing Agent combined with a bit of SSRI activity. The main advantage is that it does not have any unpleasant side effects that are seen with other anti-depressants available in pharmacy stores.

As an anxiolytic, Sceletium works really well. Sceletium slows down the hyperactivity of the mind and an abnormally active autonomic nervous system. If you suffer from problems like overthinking and anxiety, Sceletium is perfect for you.

Anxiety is closely associated with social phobia. For people who find it tough to communicate, Sceletium can prove to be especially useful. The herb makes it all the more enjoyable for people to socialize. It proves to be a lot more than just a placebo.

Obsessive Compulsive Disorder can also be treated with the help of Sceletium. It is found to be immensely productive for the same. It enables the perfect coordination between the mind, body, and heart, thereby leading to a non-obsessive and non-compulsive state.

How does Kanna work?

Kanna consists of four main components, namely Mesembrine, Mesembrenone, Mesembrenol and Mesembranol. The major alkaloids are Mesembrine, and Mesembrenone. The former works as an effective Serotonin Uptake Inhibitor while the latter works as both Serotonin Reuptake Inhibitor and PDE4 inhibitor. These chemicals undergo reactions with serotonin and dopamine receptors present in the brain. It is assumed that this activity pertaining to the specific receptors like nicotinic, dopamine, and noradrenaline is responsible for the euphoric effect.

What are the Kanna (Sceletium) side effects?

It is still somewhat unclear whether Kanna is safe to use. It has been reported to cause headaches, loss of appetite and depressed mental state. People also tend to get intoxicated on using it in excess quantities or not letting it stand after fermentation. Some patients also experience soft stool, temporary feeling of anxiousness after treatment initiation and insomnia. It can also lead to sedation that can be corrected if you take medicine at night in a single dose of 50 mg.

There is hardly any literature on its usage in pregnancy and breastfeeding. Due to the scarcity of resources, it is best not to use it. After all, it is better to be a safe rather than sorry.

How to use Kanna (Sceletium)?

Kanna is generally taken after breakfast and lunch once or twice daily in the dosage of 50 mg or 100 mg. For some patients, it can also be used 100 mg twice per day. For drug rehabilitation, patients can take it up to 200 mg per day under the strict supervision of a physician or psychiatrist. An important point to have in mind here is that it should be taken in a lighter dose at the outset so that there are no side effects.

Is it legal to use?

Kanna can be legally bought, possessed, cultivated and distributed even if you do not have a license or prescription as it is not a controlled substance in any country. This is true for parts of the plants as well as the extracts. However, there may be specific rules in different countries for its use of a drug or supplement.

Users experience of Kanna (Sceletium)

I was a happy go lucky kind of a guy until I failed in my first-year college examination. Anxiety, depression and all sorts of negative vibes took over me. Life became a burden. I could not understand who to turn to and what to do. Amidst all the chaos of life, I came across Kanna on Drugs-Forum. I thought to give it a try according to the dosage specified. I had not expected it to work, but to my sheer surprise, it worked great to treat my anxiety and restlessness. I felt calm and composed enough to concentrate on my studies. It helped me to score well in my next exam and prove myself. Had it not been for Sceletium, I guess my life would still have been sad and desperate.

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Are you suffering from stress which is bounding you to perform your daily tasks? Do you feel restless and pressurized even for the minor things? Do you fail to sleep at night and end up with insomnia? If the answers to these questions are yes then you are suffering from anxiety. This is not a thing to get more worried about. The good news for you is that you can treat it yourself. Yes, you have heard it right. This article will help you to understand that how Kava Kava works to treat anxiety and depression with scientific evidence.

Does Kava Kava help to treat anxiety?

Kava Kava is a native plant of the Western Pacific region. It is used to prepare a traditional drink which is alternative to tea and coffee. It has psychoactive properties which mainly involves treating mental problems. For centuries, it has been a part of traditional medicine of various cultures. Kava has many therapeutic characteristics, first and most important is being a antispasmodics which relieves nervous stress. A study on the aqueous solution of Kava was named as Kava anxiety-depression Spectrum Study (KADSS) which had 60 volunteers of depression. Five Kava tablets were given to them per day and the results after three weeks were astonishing. It proved to be a significant anxiolytic and anti-anxiety treatment for the clinical patients. It also helps to overcome severe mood swings which lead to mental disorders.

The Journal Of Alternative And Complementary Medicine has published research which provides a comprehensive review of Kava to be helpful for depression, bipolar disorder, seasonal affective disorder, generalized anxiety disorder, social phobia, panic, obsessive-compulsive disorder and post-traumatic stress.

Scientific evidence of Kava to treat anxiety

A detailed study by Adelphi University and Rutgers University in 2013 studies anxiolytic medications and the green alternatives. They termed Benzodiazepines e.g. Valium, Xanax, etc. to work for controlling serotonin by preventing the re-uptake of serotonin from synapse but these medicines fail to correct the lack of serotonin production. The research offered various herbs to help for anxiety control, regarding Kava Kava to be the best for reducing stress.

A similar study by School of Psychiatry and Clinical Neurosciences, University of Western Australia studied the complementary and alternative medicine in the treatment of physical and psychiatric symptoms and disorders in Western populations. They found Kava-Kava to be working best for mild to severe depression.

Research on herbal medicine’s affectivity for depression was reviewed by Global Neuroscience Initiative Foundation, the USA which is published in Nutrition Journal explains the analysis of 24 published types of research. Eight combination treatments and 2619 participants who were tested through various measures. 1786 patients were labeled to be suffering from anxiety and depression. With randomized control trials, 71% of the patients showed a positive result for an herbal treatment. There were minimum or no side effects.

How to take Kava to cure stress?

Kava Kava is available in whole root form which can be used to make a drink of your choice. However, it may be of a mild or high concentration, with a personal choice. The traditional recipe contains one tablespoon of the powdered Kava to be mixed with 1 cup water.

Kava Kava for anxiety has a different method to use. Commercially it is available as powder and supplement form which are carefully designed by authentic pharmaceutical companies. With a general dose of minor stress to high dosage in high stress, Kava supplements help to overcome stress and depression. Ideally, Kava root should be grounded to powder and mixed with the cold water. Later it should be carefully filtered and boiled for use.

What is the Kava dosage for anxiety?

Being a safe herbal choice, Kava has a different dosage to heal body stress which depends on the health status of the user. The German Commission recommends the ideal dosage to be 60-120mg per day with no more than three months (without any other medical condition). However, a general range is from 70mg to 300 mg of it which promotes cellular balance and a resting stage for the body.

Initially, a clinical research from 1919 studied 58 patients o anxiety who were given 70mg of Kava supplement which helped them to reduce the body stress at a significant rate. A comparison of this studies with the latest research. The American Herbal Product Council has warned people to never exceed the daily kavalactones, the phytochemicals of Kava root, over 300mg per day. For most of the people, 70mg works well as proved by the research but the new light dose for reducing the anxiety is prescribed to be between 150-250 mg which treats all types of stress.

For treating depression along with stress linked insomnia, Kavalactones of 180mg to 210mg should be taken one hour before going to bed as prescribed by Mosby (2008).

Is Kava a safe choice to be used for anxiety?

A few decades ago, Kava was available widely for chewing as an alternative remedy for anxiety, but the reports of side effects affected its sale. This lead to a ban on the fibrous root of Kava Kava for trade in USA, Germany, Canada, France and UK. Kava supplements are not banned because of their precise dosage and the doubts of Kava Kava to be harmful were falsified by many types of research later on which regained the popularity of Kava Kava to be used for treating anxiety.

A study by medical center of the University of Maryland proved Kava supplements to be safe for use. It also strengthens that the dosage should not be self-induced but prescribed by a health physician. The most recent study by Australian National Health and Medical Research Council in 2015 proved Kava to be extremely beneficial for the treatment of generalized anxiety disorder (K-GAD).

To gain the maximum benefits of Kava for treating anxiety disorders and stress, the recommended measure are advised to be followed which involve safe dosage, the quality manufacturer and the consent of a health service provider prior the use of Kava Kava supplements or drink.

The post Does Kava Kava Work For Anxiety? Kava Usage and Dosage For Anxiety appeared first on Kratomguides.com.

Have you used opiate drugs to treat your pains but ended up with an addiction to it? If yes, this article is very helpful for you to understand that how can you withdraw the addiction of opiate drugs by a simple herbal solution. It is none other than the traditional Asian plant Kratom.

What are opiate drugs?

According to the survey by National Institute on Drug Abuse (NIDA), around 26.4 million and 36 million people abuse opiate drugs globally which include the prescription based painkillers and illegal drugs such as heroine. These drugs are based on changing the brain’s response to the stimuli of pain, stress or anxiety by creating a high feeling. The central nervous, cardiovascular, and respiratory system have receptors which are disturbed by the opiate drugs.

Due to the dangerous side effects and health risks, people are tending more towards the green alternatives after 1990’s as suggested by Center for Alternative Medicine Research and Education’s report of 1998. It was a seven-year-long study which was completed with the survey of 1539 adults in 1991 and 2055 in 1997. It suggested the increase in the population seeking alternative therapies.

Opiate addiction and withdrawal

Opiate drugs initiate a feeling of well being which becomes addictive to many people. Initially, it is given to the patients to treat pain and reduce body stress but not for getting high. The effect of Kratom is different on different people. A high dosage of Kratom may lead to a cardiac arrest or respiratory failure. In the attempt to get a relaxed feeling, people often end up with serious side effects of high potential dosage.

The withdrawal of opiates is extremely unpleasant. However, it is not life threatening. Withdrawal from alcohol and different drugs can be dangerous, but Kratom has a safer withdrawal scheme.

Does kratom work for opiate withdrawal?

Kratom is a natural plant of Southeast Asia, Thailand, Malaysia, and Myanmar. Scientifically, it is called Mitragyna speciosa, and it belongs to the coffee family “Rubiaceae.” Kratom leaves have been part of traditional Asian medicine for its amazing medicinal properties.

According to a study by H Ridley in 1897, it was concluded that Kratom leaves are nature’s help for opiate withdrawals and dependency. Over the years, it has been used to treat various conditions as depression, PTSD, pain, fatigue, diabetes, and stress. Kratom is not itself an opioid, drug or medicine. It just produces a euphoric feeling which helps to minimize the withdrawal symptoms and balance the work of receptors for pain management.

A joint study (2008) was carried out by Department of Emergency Medicine, University of Massachusetts, Department of Medicinal Chemistry and School of Pharmacy of the University of Mississippi in collaboration with Alcohol and Drug Abuse Research Centre, Harvard Medical school the USA. They found that the use of Kratom controlled the self-treatment of chronic pain and opioid withdrawal. The alkaloid of Kratom mitragynine binds to the receptors Mu- and Kappa-opioid which produces an effective method for overcoming withdrawal.

Which type of kratom treats opiate addiction?

Commercially, Kratom is available under many names for different purposes. The particular Kratom to treat opiate addiction and after effects, Red Vein Kratom is widely used. It is also called Red Indo, Red Bali Kratom for its origin. This type of Kratom majorly treats as a pain relief and opiate and heroin withdraw. Bali Kratom works to relax and energizes the body, and Maeng Da Kratom stimulates the effects.

How does kratom help to quit opiate drugs?

Kratom has above 25 different types of alkaloids in them which include 7-Hydroxymitragynine, 9-Hydroxycorynantheidine, and Mitragynine which are considered to be enhancing the potential of Kratom. These alkaloids work as opioid agonist which attracts opioid receptors of the brain. These opioid receptors control mood, pain management, depression, and anxiety. A higher dose of Kratom significantly increases the effects and a lower dose just works as a stimulator. The alkaloid mitragynine has proved to be significant in suppressing opiate withdrawal.

A study by Graduate School of Pharmaceutical Sciences, the Chiba University of Japan in 2002 explained Mitragynine to be effective analgesic mediated by opioid receptors.

Different types of kratom exhibit different properties

The effect of Kratom largely depends upon person to person. Also which type of Kratom used. The effects can be energizing or relaxing as per dosage is set and the effects usually last from 30 minutes to 6 hours. The Kratom samples from the various geographical region may exhibit different properties.

What is the Ideal dosage of kratom to quit opiate drugs?

Commercially, Kratom comes in different levels. For a general usage, one teaspoon is the minimum quantity to work for an adult which nearly is 4 grams of the Kratom powder. One tablespoon is equal to 10 grams of the powder. Most opiate and heroin withdrawal is treated from 2 tablespoons every 6 hours, but for stress and anxiety, the small dosage recommended. Taking four antacid tablets each of 750 mg one hour before taking Kratom increases its potential because antacids raise the natural PH of human stomach which makes Kratom absorb more.

How to use kratom?

This question depends upon a personal choice. Kratom is sold in different forms such as crushed leaves, powder, capsules, etc. You can select your options. The most common method to use it by adding it to drink or food. Capsules are the easiest way to consume Kratom. Taking tablets are easy and convenient. It is available in the market with various trade names.

A tea can be made of Kratom is a pleasant way to take it.

A combined latest research from 2015 on Evolution of an enhancer from a traditional use to increase work and productivity in Southeast Asia to a recreational psychoactive drug in Western countries suggests Kratom be a safe and natural choice for personal use.

Other herbal solutions for opiate withdrawal

There are some other plants which provide help against opiate drugs. Some of them as following.

Blue Lotus

It is a natural aphrodisiac but a weak painkiller as compared to Kratom. It helps to relieve muscle pain, migraines, cramps and joint pains. It is also used as tea by boiling the plant parts in water.

Kava Kava

Kava-Kava gives a mild euphoric effect but works exceptionally well to treat anxieties. It has been used in traditional medicines and commonly available in supplement form.

Wild Opium Lettuce

Anciently, this herb was a popular painkiller and a mild sedative. As a part of tea, 1-2 grams of the lettuce sap is used in tea to treat body pains.

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Everyone knows about smoking cannabis, but many of us don’t know that it is a medicinal plant with powerful chemical constituents. Similarly, kratom is popular for its possible hallucinating effects, but the real reason for its success and general availability is not the popular trend but the phytochemicals it contains and the therapeutic potential of those chemicals which proves to be significant for many diseases.

The recent century discovered the magical combination of kratom and cannabis which has extremely high medicinal and psychological potential. Kratom and cannabis have been used for hundreds of years in tradition medicines.

About kratom and cannabis combined benefits

Kratom is a natural herb that has become a standard house dietary supplement after its medicinal properties have been made universal. Marijuana also known as cannabis is one of the most searched herbal product. It has been recently started to use into medicines in the USA. These herbs are useful in their way, but for a well-proportioned medication, a combination of both is used. Although both these herbs are familiar in a negative way too but for a medical reason, the combination has not shown any problem or health hazard and no study has reported harmful effects of this combination which makes it a safe choice to have.

Legal status of kratom and cannabis

The fresh Kratom is banned in some countries due to the high concentrations of phytochemicals it contains. Later on, high potency of kratom taken by people lacks the proper dosage and result in serious health concern.

After some medical researchers proving kratom to be safe for human consumption, the trend of availability of kratom in the form of powder or pills has made legal. The kratom supplements are available everywhere even without perception.

Cannabis, on the other hand, is an illegal herb which is not easily accessible. Its legal status is varied in different countries, but for medicinal use, it is legal. Both this substance, when combined, have adverse effects on the brain and treat multiple problems of us.

Medical effects of kratom and cannabis

Besides enhancing mental condition, the combination of cannabis and Kratom has amazing medicinal properties. The synergy between these two herbs is for those who are surfers of chronic pains and for opiate withdrawal. Some of the benefits of these herbs are medically tested and proved, but an advanced level research is still under analysis for detailed information on these magical herbs.

Kratom and cannabis for pain relief

The best combination to cure body pains is the combination of kratom and cannabis. The phytochemicals are high in both which when combined becomes a powerhouse for treating illnesses. It’s a natural analgesic which fights with every type of diseases, and the combination can be used for following.

• Back pain
• IBS
• Fibromyalgia
• Knee and Joints pain
• Mechanical Injuries
• Neck pain
• Multiple Sclerosis
• Endometriosis

How does kratom and cannabis combination work for pain?

Kratom’s pain relief potential is due to two alkaloids 7-hydroxymitragynine and mitragynine. These two alkaloids work like body’s natural hormones and target the two receptors delta opioid and MU which send pain signals to the brain for the essence of suffering. It works for half an hour to one hour. The cannabis plant has a wide variety of alkaloids. Out of 66, THC, CBD, and CBG are those who work for pain management. The combination first decreases the pain sensitivity and then it increases the body’s tolerance towards pain.

Kratom and cannabis combination for opiate withdrawal

Kratom has proven to be highly effective, but the combination of it with cannabis makes it even more efficient. There is no outstanding published work from research sector, but the popularity of its working has made many scientists aware of the medicinal properties of them as a combination. Many user’s anecdotal reports say that this treatment has helped them in an efficient manner. It has dramatically reduced some of the major symptoms which include RLS, panic, and anxiety. There are no reported side effects of the combination to be used for opiate withdrawal.

Dr. Sean Breen from Medical Cannabis of Southern California narrates a patient who overcomes his drug addiction by using the combined therapy. Doc explains that this combination can reduce anxiety, stress, agitation and balanced sleeping hours and makes your digestive track clean and fit.

Psychological benefits of kratom and cannabis mixture

Similar to the medicinal effects, the psychological consequences of this combination of cannabis and kratom are unmatched. People who have used this combination indicate a relaxed and tension free force in their life. According to user reviews, the most common benefits of this combination are as following.

• Antidepressant
• Reduces stress
• Ends anxiety
• Induces euphoria
• Magnified sensory receptors
• Increased sedation (Urge to sleep)
• Helps against psychotic disorders

How to take cannabis and kratom together?

While mixing both the herbs, proper care is required. Since both these plants long associated with the side effects, the quantity and concentration should be properly administered. High dose of kratom will induce nausea. Cannabis supply should always be less than kratom. The kratom can be taken in the form of a drink (tea) and later on cannabis can be smoked with a gap of one hour to two hours as suggested by an online forum of Blue light.

The chemicals involved in both make the body hyperactive, and concentration is enhanced which results in increases effectively. The dosage is experimental however a physician should be consulted before taking this combination for medical reasons.

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Have you ever used Kratom for its multiple benefits including opiate withdrawal? Are you happy with the results but can’t get enough of it? Good news for you is that you can get maximum benefits of Kratom in multiple ways. This article will elaborate one of the most efficient combinations of Kratom with Chamomile.

Kratom – does it work for you?

Kratom is a herb directly derived from a tree without involving any chemicals in it. It is native to Southeast Asia where it is an attractive part of traditional medicine and celebratory drinks for hundreds of years. One collected, Kratom leaves are dried and ground into fine powder. Its root is also dried and used to make powder. This powder is easily available in the market in open form or in dietary supplement. It can even be purchased online.

Although it is not an opiate itself, it shows opiate-like effects which are not addictive. It is highly recommended to the surfers of chronic pains, anxiety, and stress. Kratom is a healthy alternative to the commercially available pain killers with no side effects.

How to potentiate Kratom effects?

Millions of the people get benefits from Kratom globally. It can be used for chronic pain relief, depression, stress and to boost immunity as well as energy. It is extremely beneficial for a migraine and mental disorders. But there is a way to get the benefits of Kratom at a maximum rate. The affectivity is doubled, and there are no side effects associated with it.

Potentiating is a technique to make the effect of one thing more so that it gives multiple benefits to the user. The potentiator of Kratom would help to activate the vital ingredients of it by reducing the reaction time. It would also contribute to making alkaloid mix functional inside the plant extract. The potentiator is mostly an herbal based compound which has its health benefits too.

In our previous article “how to increase the strength of kratom?, we have mentioned the best Kratom potentiators. These natural potentiators when combined,  the effects are increased more than doubled which gives an overwhelming joy to the user. The additional substance would also cover the unpleasant taste and smell of Kratom. There are so many options to be taken with Kratom, among which each one has its unique properties. Trying different potentiators is appreciated, but the one with most likely effects with least risks should be preferred such as chamomile.

Chamomile – how is it beneficial?

Chamomile in an ancient herb which has the broad range of benefits since early times. Many of the people take it for relaxing the stomach problems or for insomnia. The two types of chamomile which have therapeutic effects on us are German chamomile (Matricaria rent Utica) and Roman chamomile (Chamaemelum Nobile). Among these two, German chamomile is used more and has scientifically proven results. Chamomile flower is easily available in the market in dried form. Infused extracts of chamomile to make tea or tinctures, concentrated in alcohol are also available for edible purposes.

Chamomile as Kratom potentiator

Chamomile increases the efficacy of Kratom and has so many support involved. Chamomile is one of the most famous potentiators which works to improve progression and gives extra benefits. Chamomile and Kratom can be infused to make tea as suggested by the user manual of Kratom. For that one part of chamomile tea or powder is mixed with one part Kratom later on mixed with water, boiled and used. Some other methods involve using a Kratom capsule and sprinkling over chamomile tea for easing the process.

Advantages of Kratom and chamomile combination

As a combination, the potential of both ingredients, Kratom and chamomile are increased. It works like magic as the analgesic for the whole body. It reduces internal inflammations, wounds and opens a blocked chest. It works best for skin related problems such as psoriasis, eczema, rashes and allergy. Since they are taken in the form of hot tea, it balances the natural Ph of the stomach, provides relief to a sore throat, balances the hormones and cures sleeping disorders. Although studies are limited to the combination of chamomile and Kratom personal usage and user reviews on different forums prove it to be working best for the health. A discussion by Reddit users concluded Kratom to be best when combined with chamomile.

Is this combination safe?

Kratom and chamomile both are herbs which have no side effects. However, some people may be allergic to chamomile for the pollen sometimes present inside it. One should always check it for allergies before using. There is no other health relate risks involved with it.

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Taking Kratom with Coffee is true synergism. Kratom and Coffee are psychomotor stimulants that act primarily to stimulate the central nervous system (CNS). Psychomotor stimulants like Coffee and Kratom, cause excitement and euphoria, decrease feelings of fatigue and increase motor activity. Mixing Kratom and Coffee potentiates the effects of the two drugs.

What is Coffee made up of and how does it work?

The main constituent in coffee is a type of methylxanthine known as caffeine, the most widely used stimulant in the world. Caffeine works in our body by different mechanisms. It causes translocation of extracellular calcium, an increase in cyclic adenosine monophosphate and cyclic guanosine monophosphate generated by interference of phosphodiesterase and blockade of adenosine receptors. Growth in camp and cGMP enhances the stimulatory effects and inhibition of phosphodiesterase enzymes prevents the destruction of these second messengers (cAMP, cGMP).

Action of Coffee on the human body

The caffeine included in one to two cups of coffee (100-200mg) causes a reduction in fatigue and increased mental sharpness as a result of stimulating the cortex and other areas of the brain. Consumption of 1.5g of caffeine (12-15 cups of coffee) produces anxiety and tremors. The spinal cord is stimulated only by very high doses (2-5g) of caffeine.

A high dose of caffeine also acts on heart, causing it to beat rapidly and contract with greater force. It also has a mild diuretic action that increases the urinary output of sodium, chloride, and potassium. It enhances the secretion of hydrochloric acid from the gastric mucosa. It relaxes the smooth muscle of bronchioles and thus it can be used in patients with asthma.

Why mix Kratom with Coffee?

For many people, the morning ritual comprises of drinking a cup of coffee and then heading to the office. Consuming Kratom may affect this ritual but it’s no more a problem, as combining coffee with Kratom can make you even more energetic and alert. Though the two drugs are bitter in taste, adding sugar and cream can help substantially. Kratom should, however, be ground well so that it can mix with coffee quickly.

Kratom and Coffee combination effects

Taking Kratom and Coffee together means that you are expecting to have stimulatory effects. However, this may not be the case. High doses of Kratom usually end up in sedation while small doses of Kratom are responsible for giving you that stimulatory effect. Therefore, it is necessary that you take Kratom at small doses. Otherwise, the relaxing effects of Kratom will negate the stimulation caused by Coffee.

Mixing the two drugs and then consuming it will make you feel energetic. Drinking too much coffee can be unpleasant it causes anxiety, and one becomes jittery, on the other hand as mentioned earlier, taking high doses of Kratom will allow you to have a soothing feeling and a relaxed state of mind. To amplify the positive effects of both drugs, mix them, and you will get a stronger and a long-lasting boost of energy.

How to take Kratom with Coffee?

You can either mix Coffee with Kratom or make coffee before consuming Kratom. Either way, it will show synergism.

When mixing Coffee with Kratom, ensure that you use milk or cream and sufficient sugar to get rid of the bitter taste. You can use a coffee maker to brew Kratom-Coffee mix. If you do not have Kratom powder, instead you have Kratom leaves, then make Kratom tea and mix it with coffee.

Avoid overheating of Kratom as the alkaloids can get denatured. After boiling water, wait for 1-2 minutes to let the water cool down, then add the desired amount of Kratom powder and coffee. Stir it till it dissolves properly. You can also go for Mixing Kratom with iced coffee.

Kratom and Coffee mixture doses

1. Small doses: Kratom 1-2grams
2. Medium doses: Kratom 2-4.5grams

Coffee can be taken in the desired amount. However, to avoid the adverse effects that come with a high dose of Coffee, use coffee within the range of 0.5-1.5 grammes. If you are tolerant to the effects of high doses of Coffee, you can consume more, but the treatments mentioned above are for beginners. If you are using energetic strains of Kratom, then use a smaller dose of Kratom.

Beneficial effects of coffee

Coffee helps you lose weight by decreasing appetite for sugary food.

1. It helps you boost your physical performance by raising levels of adrenaline in your body.
2. It also helps in fighting depression.
3. It helps you burn fat.
4. It increases mental alertness and helps you focus better.
5. It lowers the risk of death by reducing the risk of cancer, stroke, Parkinson’s disease and Type II Diabetes.
6. It helps you in memorizing things and thus prevents the onset of Alzheimer’s disease as well as dementia.
7. It has an antioxidant action in the body.

Adverse effects of Coffee

Moderate dosages of caffeine create insomnia, anxiety, and agitation. A high dose is required for toxicity, which is manifested by emesis and convulsions. The lethal dose (10g) is about 100 cups of coffee that can induce cardiac arrhythmias. Lethargy, irritation, and headache occur in users who routinely consume more than 600mg of caffeine per day and then suddenly stop.

Conclusion

Taking Kratom with Coffee is not a healthy idea, but it’s not something that has serious adverse effects. It is necessary that you keep a note on your diet and sleep pattern to avoid getting into any health issues. To be on the secure side start including a little dose of Kratom and coffee and then make your way to higher doses. Do not start with a high dose as you may end up vomiting everything. Also, it is important that you add sugar and cream into your coffee when Mixing Kratom with it otherwise the bitter taste can make you gag or give you an upset stomach.

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